ArticleNutrition & metabolism2025
Exercise-induced metabolomics and its association with metabolic health in adolescents.
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Sex differences in response to a short-term training program intervention in obese adolescents: a plasma metabolomics study.Biology of sex differences · 2026Article
- Metabolic Adaptation during Cardiac Exercise Rehabilitation in Patients after a First Myocardial Infarction.Journal of proteome research · 2026Article
- Article
- Chain-mediated pathways of adults socioeconomic status affecting physical fitness in Macao: the role of motor skills and moderate to vigorous physical activity.Frontiers in public health · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundWhile exercise training has been shown to improve various aspects of adolescent metabolic health, such as blood pressure, insulin resistance, and dyslipidemia, the underlying metabolic mechanisms remain poorly understood. No study has examined the metabolomic changes to identify potential mechanisms and explore biomarkers that predict exercise benefits in adolescents.
methodsWe used propensity score matching to select 54 pairs of adolescents (ages 12-14 years) with and without long-term exercise training. Body mass index (BMI), waist circumference (WC) and metabolic indicators including blood pressure, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and triglycerides (TGs) were assessed at enrollment and 1-year follow-up. Untargeted metabolomics was analyzed at enrollment. The associations between metabolites and clinical metabolic indicators were tested.
resultsMetabolomic analysis revealed 73 differential metabolites between exercise and non-exercise groups, with 59 metabolites associated with metabolic health indicators. Among them, a group of eicosanoids were consistently upregulated and negatively associated with diastolic blood pressure (DBP), HOMA-IR, or TGs, suggesting their potential roles in exercise-related improvements. Receiver operating characteristic analysis showed better predictive performance for exercise benefits on DBP and TGs using papaverine and azelaic acid compared to BMI and WC.
conclusionsAdolescents with long-term exercise are associated with improved metabolic health. Metabolomic profiles provide novel insights into the underlying mechanisms and offer useful biomarkers for predicting exercise benefits.
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