Evidence map›Paper›PMID 40405194›Full record

ReviewBMC biology2025

ER-plastid contact sites as molecular crossroads for plastid lipid biosynthesis.

Carolina Huercano, Miriam Moya-Barrientos, Oliver Cuevas, Victoria Sanchez-Vera, Noemi Ruiz-Lopez

Abstract readReview
In one paragraph

Review in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Mce transport systems inJournal of bacteriology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carolina Huercano *Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de Teatinos, Málaga, 29071, Spain.
Miriam Moya-Barrientos *Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de Teatinos, Málaga, 29071, Spain.
Oliver CuevasInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de Teatinos, Málaga, 29071, Spain.
Victoria Sanchez-VeraInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de Teatinos, Málaga, 29071, Spain.
Noemi Ruiz-LopezInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Universidad de Málaga, Campus de Teatinos, Málaga, 29071, Spain. noemi.ruiz@uma.es.

Funding

MCIN/AEI/ PID2020-120227RJ-I00MCIN/AEI/ 10.13039/501100011033 PRE2019-087710MCIN/AEI/10.13039/501100011033 PID2021-127649OB-I00Universidad de Málaga grant A.3.1. from II Plan Propio de Investigación
6 · The paper itself

Abstract

Membrane contact sites are specialized regions where organelle membranes are in close proximity, enabling lipid transfer while preserving membrane identity. In plants, ER‒chloroplast contact sites are critical for maintaining glycerolipid homeostasis. This review examines the lipid-modifying and lipid-transfer proteins/complexes involved in these processes. Key proteins at these sites, including components of the TGD and VAP27‒ORP2A complexes, as well as Sec14 proteins, facilitate lipid exchange. Additionally, the roles of lipid-modifying proteins at these contact sites are discussed. Despite significant progress, further research is needed to identify additional proteins, investigate ER‒chloroplast dynamics under stress and explore ER contact sites in non-chloroplast plastids.

Indexed as

Endoplasmic ReticulumLipid MetabolismLipidsPlastidsPlant ProteinsPlantsLipidsPlant ProteinsChloroplastContact sitesEndoplasmic reticulumGlycerolipidLipid transferNTMC2 T5ORPPlastidSFH5TGD4

Identifiers

PMID40405194
PMCPMC12096540

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.