Evidence map›Paper›PMID 40405242›Full record

ReviewJournal of nanobiotechnology2025

Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives.

Junsi Luo, Yiteng Cui, Laijun Xu, Junyi Zhang, Jinhong Chen, Xumin Li, Bin Zeng, Zhiyuan Deng, Longquan Shao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  15. Nanotechnology Meets Immunotherapy: Crosstalks Against Cancer.Immunity, inflammation and disease · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junsi Luo *Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Yiteng Cui *Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Laijun XuStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Junyi ZhangHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Jinhong ChenStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Xumin LiStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Bin ZengSchool of Stomatology, Changsha Medical University, Changsha, 410219, China.
Zhiyuan DengHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China. drdengzhiyuan@csu.edu.cn.
Longquan ShaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China. shaolongquan@smu.edu.cn.

Funding

SouthernMedical University Stomatology Hospital'Scientific Research Cultivation Program' - PostdoctoralSpecial Project PY2023009the Major Scientific and Technological Project of Changsha kh2301026the National Natural Science Foundation of China 82201081the National Natural Science Foundation of China 82271025the Natural Science Foundation of Hunan Province S2022JJQNJJ2963
6 · The paper itself

Abstract

With the rapid development of nanotechnology, layered double hydroxides (LDHs) have attracted considerable attention in the biomedical field due to their highly tunable composition and structure, superior biocompatibility, multifunctional bioactivity, and exceptional drug delivery performance. However, a focused and comprehensive review addressing the role of LDHs specifically in tissue regeneration has been lacking. This review aims to fill that gap by providing a systematic and in-depth overview of recent advances in the application of LDHs across various regenerative domains, including bone repair, cartilage reconstruction, angiogenesis, wound healing, and nerve regeneration. Beyond presenting emerging applications, the review places particular emphasis on elucidating the underlying mechanisms through which LDHs exert their therapeutic effects. Although LDHs demonstrate considerable promise in regenerative medicine, their clinical translation remains in its infancy. To address this, we not only provided our insights into the personalized problems that arise in the application of various tissues, but also focused on discussing and prospecting the common challenges in the clinical translation of LDHs. These challenges include optimizing synthesis techniques, enhancing biosafety and stability, improving drug-loading efficiency, designing multifunctional composite materials, and establishing pathways that facilitate the transition from laboratory research to clinical practice.

Indexed as

HydroxidesNanomedicineRegenerative MedicineTissue EngineeringAnimalsBiocompatible MaterialsDrug Delivery SystemsHumansWound HealingBiocompatible MaterialsHydroxides2D nanomaterialLayered double hydroxidesRegenerative nanomedicineTissue engineering

Identifiers

PMID40405242
PMCPMC12096525

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.