Evidence map›Paper›PMID 40405463›Full record

ArticleHGG advances2025

A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci.

Susan Adanna Ihejirika, Alexandra Huong Chiang, Aryaman Singh, Eunice Stephen, Han Chen, Kaixiong Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Susan Adanna IhejirikaInstitute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
Alexandra Huong ChiangDepartment of Genetics, University of Georgia, Athens, GA 30602, USA.
Aryaman SinghDepartment of Genetics, University of Georgia, Athens, GA 30602, USA.
Eunice StephenDepartment of Genetics, University of Georgia, Athens, GA 30602, USA.
Han ChenHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Kaixiong YeInstitute of Bioinformatics, University of Georgia, Athens, GA 30602, USA; Department of Genetics, University of Georgia, Athens, GA 30602, USA. Electronic address: kaixiong.ye@uga.edu.

Funding

Gene-Environment Interactions in Human Evolution and Complex TraitsR35GM143060 · NIGMS · UNIVERSITY OF GEORGIA · PI YE, KAIXIONG · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM143060
6 · The paper itself

Abstract

Fish oil supplements (FOS) are known to alter circulating levels of polyunsaturated fatty acids (PUFAs) but in a heterogeneous manner across individuals. These varied responses may result from unidentified gene-FOS interactions. To identify genetic factors that interact with FOS to alter the circulating levels of PUFAs, we performed a multi-level genome-wide interaction study (GWIS) of FOS on 14 plasma measurements in 200,060 unrelated European-ancestry individuals from the UK Biobank. From our single-variant tests, we identified genome-wide significant interacting SNPs (p < 5 × 10

Indexed as

DietFatty Acid DesaturasesFatty Acids, UnsaturatedFish OilsReceptors, G-Protein-CoupledDelta-5 Fatty Acid DesaturaseDietary SupplementsFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFADS2 protein, humanFatty Acid DesaturasesFatty Acids, UnsaturatedFish OilsReceptors, G-Protein-Coupledfish oil supplementsgene-diet interactionsomega-3polyunsaturated fatty acids

Identifiers

PMID40405463
PMCPMC12172259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.