Evidence map›Paper›PMID 40405669›Full record

ArticleEpigenetics2025

Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta.

Jagadeesh Puvvula, Joseph M Braun, Emily A DeFranco, Shuk-Mei Ho, Yuet-Kin Leung, Shouxiong Huang, Xiang Zhang, Ann M Vuong, Stephani S Kim, Zana Percy and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jagadeesh PuvvulaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-4927-3507
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, USA.
Emily A DeFrancoDepartment of Obstetrics and Gynecology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Shuk-Mei HoDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Yuet-Kin LeungDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Shouxiong HuangPathogen-Host Interaction Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Xiang ZhangDepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Ann M VuongDepartment of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, Las Vegas, NV, USA.
Stephani S KimHealth Research, Battelle Memorial Institute, Columbus, OH, USA.
Zana PercyDepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in childrenR01ES028277 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2017 to 2022
$3.4M
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimagingR01ES033054 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2021 to 2025
$3.3M
RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm qualityR01ES032675 · NIEHS · UNIV OF ARKANSAS FOR MED SCIS · PI Shuk-Mei Ho, Yuet-Kin Leung · 2022 to 2026
$2.4M
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic HealthR01ES032836 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2021 to 2024
$2.4M
BLRD VA I01 BX005395BLRD VA IK6 BX006182NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES028277NIEHS NIH HHS R01 ES032675NIEHS NIH HHS R01 ES032836NIEHS NIH HHS R01 ES033054
6 · The paper itself

Abstract

The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment, methylation profiles vary by tissue due to variance in cell populations, function, and life stage. As tissue differences extensively contribute to the DNA methylation patterns, using surrogate samples such as cord blood may result in inconsistent findings. In this study, we aim to quantify the correlation of

Indexed as

DNA MethylationEpigenesis, GeneticFetal BloodPlacentaAdultCpG IslandsFemaleHumansLeukocytes, MononuclearPregnancycord blood mononuclear cellsDNA methylationplacenta

Identifiers

PMID40405669
PMCPMC12118431

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.