ArticleAdvanced healthcare materials2025
Engineered 3D Kidney Glomerular Microtissues to Model Podocyte-Centric Diseases for the Validation of New Drug Targets.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Kidney organoids as a platform to study plasminogen-induced injury and uPA-based therapies.Stem cells translational medicine · 2026Article
- Construction, evaluation, and applications of renal barrier-on-a-chip system.Bioactive materials · 2026Review
- Engineered 3D Kidney Glomerular Microtissues to Model Podocyte-Centric Diseases for the Validation of New Drug Targets.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Podocytopathies are a diverse group of kidney diseases characterized by podocyte injury, leading to proteinuria and reduced kidney function. This injury often disrupts cytoskeletal dynamics and cellular adhesion, causing glomerular dysfunction. Current in vitro models fail to accurately mimic the three-dimensional (3D) organization and mechanics of kidney tissue, hindering the understanding of podocyte pathophysiology and therapeutic development. In this study, 3D microtissues are developed that replicate the structure and mechanics of the glomerular filtration barrier, enabling the modeling of chemically and genetically induced podocyte injuries for drug target validation. These microtissues simulate the glomerulus's three-layer structure and hemodynamic mechanical stretch, providing a platform to evaluate relevant mechanobiological signaling pathways and podocyte dynamics. Collective cellular forces are measured to assess podocyte resilience against genetic or chemical injuries. As a proof-of-concept, podocyte injury is modeled through transient receptor potantial canonical 6 (TRPC6) overexpression, a validated target in podocytopathies, and evaluated by the TRPC6 inhibitor SAR7334. The results demonstrated a loss of podocyte contractile forces upon TRPC6 overexpression, with recovery following treatment. This highlights the potential of glomerular microtissues to model podocyte mechano-pathophysiology and serves as a robust platform for screening new therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.