Evidence map›Paper›PMID 40405809›Full record

ArticleInternational journal of surgical pathology2025

Rapid Malignant Transformation of a Biopsy Proven Sporadic Soft Tissue Schwannoma to Spindle Cell MPNST With

Madhurya Ramineni, Veronica Ulici, David G Hicks, Aaron R Huber, Gregory Dieudonne, Xi Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of surgical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madhurya RamineniDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0003-0008-8826
Veronica UliciDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
David G HicksDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
Aaron R HuberDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0003-1286-7413
Gregory DieudonneDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
Xi WangDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0001-8098-2064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) primarily originate from the neurofibromatosis 1 (NF1)- associated and/or sporadic neurofibromas. Reports of malignant transformation from a sporadic soft tissue schwannoma are rare. In most tumors documented in this context so far, the malignant component is an epithelioid MPNST with a strong and diffuse S100 positivity. We present a patient diagnosed with a sporadic soft tissue schwannoma on core biopsy, which underwent rapid malignant transformation to a spindle cell type MPNST. Somatic tumor profiling of the excision specimen revealed

Indexed as

Cell Transformation, NeoplasticNerve Sheath NeoplasmsNeurilemmomaSoft Tissue NeoplasmsTumor Suppressor Protein p53Biomarkers, TumorHumansMutationBiomarkers, TumorTP53 protein, humanTumor Suppressor Protein p53NF2 lossNRASp53 in schwannomaRICTORschwannoma malignant transformationspindle cell MPNST

Identifiers

PMID40405809
PMCPMC12446714

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.