ArticleFrontiers in cell and developmental biology2025
Genetic mechanisms of hemispheric functional connectivity in diabetic retinopathy: a joint neuroimaging and transcriptomic study.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multiscale Cortical Remodeling Following Abrupt Visual Deafferentation in Rhegmatogenous Retinal Detachment: Imaging Transcriptomics and Neurotransmitter Mapping.CNS neuroscience & therapeutics · 2026Article
- Temporal dysregulation ofResearch square · 2025Article
- Differences in the amplitude of dynamic low-frequency fluctuations in primary angle-closure glaucoma are associated with gene-molecular multi-omics.Frontiers in medicine · 2025Article
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Authors and funding
3 authors.
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Abstract
Background: DR represents a major cause of global vision loss; however, the genetic basis of functional homotopy,a critical neurobiological metric reflecting interhemispheric functional synchronization, remains largely unexplored. Emerging evidence suggests that DR patients exhibiting aberrant VMHC may potentially associate with distinct transcriptional profiles. These findings could provide novel mechanistic insights into the neuropathological substrates underlying DR-related visual and cognitive dysfunction. Methods: Resting-state fMRI data from 46 DR patients and 43 HCs were analyzed to compute VMHC for assessing interhemispheric functional connectivity. Spatial transcriptomic-neuroimaging associations were examined using AHBA, revealing genes significantly correlated with VMHC alterations. Subsequent analyses included functional enrichment assessment and PPI network construction. Results: DR patients demonstrated significantly lower VMHC in bilateral LING, PoCG, and PreCG versus controls, indicating impaired interhemispheric connectivity in visual-sensorimotor networks. VMHC variations spatially correlated with 4,000 genes (2,000 positive/negative each), enriched in transcriptional regulation, mitochondrial function, synaptic activity (BP/CC/MF), and lipid metabolism/N-glycan biosynthesis (KEGG). PPI network identified hub genes (ACTB/MRPL9/MRPS6,positive; H4C6/NDUFAB1/H3C12,negative) regulating mitochondrial dynamics, cytoskeleton, and epigenetics. Conclusion: This study represents the first integration of fMRI and transcriptomics to elucidate the genetic determinants underlying VMHC disruption in DR. The findings demonstrate that impaired interhemispheric connectivity in DR involves complex interactions among genes regulating neurovascular, metabolic, and neurodegenerative pathways. These results significantly advance the understanding of neurological manifestations in DR and identify potential therapeutic targets for clinical intervention.
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