Evidence map›Paper›PMID 40406432›Full record

ArticleGastroenterology and hepatology from bed to bench2024

Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma: a system biology approach.

Mitra Rezaei, Fatemeh Bandarian, Farideh Razi, Zahra Razzaghi, Ayad Bahadori Monfared, Babak Arjmand, Reza M Robati, Alireza Ahmadzadeh

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In one paragraph

Article in Gastroenterology and hepatology from bed to bench, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mitra RezaeiGenomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh BandarianEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farideh RaziDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Zahra RazzaghiLaser application in medical sciences research center, Shahid Beheshti University of medical sciences, Tehran, Iran.
Ayad Bahadori MonfaredFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Babak ArjmandCell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Reza M RobatiSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza AhmadzadehProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma via protein-protein interaction (PPI) network analysis is the main aim of this study. Background: Esophageal cancer (EC) is recognized as cancer with a very poor prognosis and malignancy. It is characterized by a high prevalence rate within the world and a very low survival rate, even with treatment. Methods: To detect esophageal squamous cell carcinoma (ESCC) related genes, gene expression profiles (GEPs) of GSE161533 from the Gene Expression Omnibus (GEO) database were considered to be analyzed. Data was evaluated via the GEO2R program to explore the significant differential genes (DEGs) associated to stages I and II of esophageal squamous cell carcinoma. Each analysis's top 250 significant DEGs were evaluated, and the non-common genes were assessed via PPI network analysis. The hub-bottleneck DEGs were determined and enriched via gene ontology. Results: Results indicate 373 significant DEGs discriminate stage I from stage II. PPI network analysis associated with gene expression assessment showed that COL1A1, SERPINE1, PDGFRB, AURKA, TGFBI, LGALS3, BRCA1, and TFRC are the critical DEGs which are related to ESCC transition state from stage I to II of disease. A total of 13 biological processes and molecular functions were related to the crucial genes. Conclusion: In conclusion, the Upregulation of COL1A1, SERPINE1, PDGFRB, AURKA, TGFB1, and LGALS3 and downregulation of BRCA1 and TFRC in stage II of ESCC relative to stage I were pointed out as the key events which are associated with promotion of stage I to stage II transition.

Indexed as

Esophageal cancerexpression profilesGene Expression OmnibusProtein interaction.

Identifiers

PMID40406432
PMCPMC12094509

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.