Evidence map›Paper›PMID 40406514›Full record

ArticleFrontiers in cellular and infection microbiology2025

Gut microbiota differences linked to weight gain and ART in people living with HIV are enterotype specific and minor compared to the large differences linked to sexual behavior.

Jan Kehrmann, Alireza Dostmohammadi, Anna-Lena Stumpf, Lara Best, Leah Consten, Hannah Sievert, Felix Maischack, Stefanie Sammet, Sarah Albayrak-Rena, Ann-Kathrin Doerr and 8 more

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Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jan KehrmannInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Alireza DostmohammadiBioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany.
Anna-Lena StumpfInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lara BestInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Leah ConstenInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Hannah SievertInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Felix MaischackDepartment of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Stefanie SammetDepartment of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sarah Albayrak-RenaDepartment of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ann-Kathrin DoerrInstitute for Artificial Intelligence in Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Katharina BohlenDepartment of Gastroenterology, Hepatology and Transplantational Medicine, University Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Otgonzul von VelsenInstitute of Medical Informatics, Biometrics, and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ivana KraiselburdInstitute for Artificial Intelligence in Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Christina B KarstenInstitute for the Research on HIV and AIDS-associated Diseases, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Farnoush FarahpourBioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany.
Folker MeyerInstitute for Artificial Intelligence in Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Stefan Esser *Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jan Buer *Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Specific antiretroviral therapy (ART) regimens are associated with weight gain in people living with HIV (PLWH). Gut microbiota is involved in weight gain in humans and animals. Human gut microbiota can be classified into enterotypes with distinct microbial and functional profiles. Methods: In a cohort of 118 PLWH, we analyzed the gut microbiome in relation to weight gain and ART regimen using Results: The enterotype was strongly associated with sexual orientation. Of the 67 individuals forming a Discussion: Differences in the composition and functional characteristics of the gut microbiome associated with weight gain and ART regimens were enterotype-specific and relatively small compared with differences linked to sexual orientation. Due to the substantial differences in gut microbiome structure among many MSM, categorization into enterotypes is useful for identifying differences in microbiome composition associated with variables such as weight gain or ART, which may be limited to a single enterotype. This may further advance the identification of microbes that contribute to weight gain or alter the gut microbiome composition in the context of the enterotype.

Indexed as

Anti-Retroviral AgentsGastrointestinal MicrobiomeHIV InfectionsSexual BehaviorWeight GainAdultBacteriaCohort StudiesDNA, BacterialDNA, RibosomalFemaleHomosexuality, MaleHumansMaleMiddle AgedPhylogenyAnti-Retroviral AgentsDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16Sartbictegravirdolutegravirgut microbiomeHIVtenofovirweight gain

Identifiers

PMID40406514
PMCPMC12095285

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.