Evidence mapPaperPMID 40406521Full record

ArticleFrontiers in cellular and infection microbiology2025

Jianhui Zhang, Shuzhen Liu, Juan Zhang, Mingzhu Feng, Shu Chen, Yinuo Zhang, Zekun Sun, Xinying Cao, Chao Gao, Xiaofei Ji and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Pathogenicity ofWorld journal of clinical oncology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianhui Zhang *Basic Medical Sciences, Binzhou Medical University, Yantai, China.
Shuzhen Liu *Basic Medical Sciences, Binzhou Medical University, Yantai, China.
Juan Zhang *Basic Medical Sciences, Binzhou Medical University, Yantai, China.
Mingzhu FengBasic Medical Sciences, Binzhou Medical University, Yantai, China.
Shu ChenBasic Medical Sciences, Binzhou Medical University, Yantai, China.
Yinuo ZhangThe Second School of Clinical Medicine, Binzhou Medical University, Yantai, China.
Zekun SunBasic Medical Sciences, Binzhou Medical University, Yantai, China.
Xinying CaoThe Second School of Clinical Medicine, Binzhou Medical University, Yantai, China.
Chao GaoThe Second School of Clinical Medicine, Binzhou Medical University, Yantai, China.
Xiaofei JiBasic Medical Sciences, Binzhou Medical University, Yantai, China.
Huilin ZhaoBasic Medical Sciences, Binzhou Medical University, Yantai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Expression of miR-362-5p and its clinical significance in GC were analyzed using data from TCGA. The effects of miR-362-5p on GC cells' proliferation and migration were examined by using CCK-8, EdU, transwell and scratch assays. MKN45 xenograft model in nude mice was employed to evaluate impacts of miR-362-5p on GC progression in vivo. Target gene of miR-362-5p was screened by bioinformatic analysis and verified by using dual-luciferase assay. Exosomes from H. pylori-infected GES-1 cell (Hp-GES-EVs) were isolated and miR-362-5p inside the exosome was detected. The uptake of exosome by GC cells was observed through fluorescence imaging and exosome-mediated pathogenesis was explored. Furthermore, the transport of exosome-mediated miR-362-5p via blood was examined. The effect of exosome-carried miR-362-5p on hepatocellular carcinoma (HCC) progression was investigated by hepatocyte's uptake, proliferation and migration assays. Results: miR-362-5p was significantly upregulated in GC tissues associated with Conclusion:

Indexed as

Carcinoma, HepatocellularExosomesHelicobacter InfectionsHelicobacter pyloriLiver NeoplasmsMicroRNAsStomach NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsexosomesgastric cancerHelicobacter pylorihepatocellular carcinomamiR-362-5pTLE4

Identifiers

PMID40406521
PMCPMC12095252

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.