ArticleJournal of the American Heart Association2025
Association of Differences in Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate With Prevalence and Incidence of Stroke.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Estimated glucose disposal rate outperforms inflammation surrogate markers in predicting cardiometabolic multimorbidity among middle-aged and older adults.Cardiovascular diabetology · 2026Article
- Association Between Differences in Estimated GFR by Creatinine Vs. Cystatin C and Stroke Outcomes: Results From the Third China National Stroke Registry.CNS neuroscience & therapeutics · 2026Article
- Serum Cystatin C and 90-Day Neurological Functional Prognosis in Acute Ischemic Stroke: Insights from a Prospective Cohort and Mendelian Randomization.International journal of general medicine · 2025Article
- Association of Intraindividual Difference in Cystatin C and Creatinine Estimated Glomerular Filtration Rate With Diabetes.Journal of diabetes research · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe intraindividual difference between the estimated glomerular filtration rates by cystatin C and creatinine (ie, eGFRdiff) is of clinical importance. This study aimed to investigate the cross-sectional and longitudinal associations of eGFRdiff with stroke using nationally representative data from the CHARLS (China Health and Retirement Longitudinal Study).
methodsThis study included 11 869 participants (aged ≥45 years) from the CHARLS 2015 for the cross-sectional analysis. A total of 11 553 participants free of stroke were recruited in 2015 as baseline and followed up to 2020 for the cohort analysis. The eGFRdiff was calculated by subtracting estimated glomerular filtration rate by serum creatinine from estimated glomerular filtration rate by serum cystatin C at baseline. Logistic regression models and Cox proportional hazards models were used to examine the cross-sectional and longitudinal associations.
resultsThe mean age of the participants was 60.3±9.6 years, and 5514 (46.5%) were men. According to the cross-sectional analysis, a negative eGFRdiff was associated with a greater prevalence of stroke (odds ratio per 1 SD, 0.841 [95% CI, 0.741-0.955]). During a median follow-up of 5.0 years, 838 individuals (7.3%) experienced incident stroke. A lower baseline eGFRdiff was associated with a greater risk of stroke onset (hazard ratio [HR] per 1 SD, 0.884 [95% CI, 0.817-0.955]). Compared with those in the midrange eGFRdiff group (from -15 to 15 mL/min per 1.73 m
conclusionsA large negative eGFRdiff was independently associated with higher prevalence and incidence rates of stroke among middle-aged and older Chinese adults.
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