ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
A Pump-Free, Hydraulic-Amplification Oscillatory Microfluidic Device for Continuous Particle and Cell Manipulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Exploiting Device Deformability for Fluid and Particle Manipulation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- A pump-free microfluidic device for integrated multi-functional testing of tumor spheroids.APL bioengineering · 2026Article
- A Pump-Free, Hydraulic-Amplification Oscillatory Microfluidic Device for Continuous Particle and Cell Manipulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Microfluidics can achieve the spatiotemporal manipulation of particles and cells in the microscale fluids, but highly relies on the accuracy of the pumping systems. To overcome this issue, a pump-free, hydraulic-amplification oscillatory microfluidic (PHOMF) device is presented, which can be actuated by fingers to handle particles and cells within the microchannel. The PHOMF device has a hydraulic-amplification module for pressure transfer and a soft microchannel module for the generation of oscillatory flows. This is made possible by the periodic transfer of finger-driven liquid pressure to the soft microchannel. This pressure causes the soft microchannel to deform and then drives the reciprocating flow of fluid volumes within the microchannel. In the oscillatory flow, particles and cells achieve single-line focusing driven by the spatially accumulated inertial and elastic lift forces. The particle elasto-inertial focusing theory in the PHOMF microchannel has been revealed. To demonstrate the system's practicality, the PHOMF device is utilized to achieve the early observation of platelet clots (3 min) and the rapid staining of cancer cells (8 min). The PHOMF device provides a miniaturized, inexpensive, and efficient detection tool for lab-on-a-chip, and has the potential to become a mass-produced, widely available, and convenient disease detection product.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.