Evidence map›Paper›PMID 40407488›Full record

ArticleBiotech (Basel (Switzerland))2025

Innovations in Proteomic Technologies and Artificial Neural Networks: Unlocking Milk Origin Identification.

Achilleas Karamoutsios, Emmanouil D Oikonomou, Chrysoula Chrysa Voidarou, Lampros Hatzizisis, Konstantina Fotou, Konstantina Nikolaou, Evangelia Gouva, Evangelia Gkiza, Nikolaos Giannakeas, Ioannis Skoufos and 1 more

Abstract read
In one paragraph

Article in Biotech (Basel (Switzerland)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Achilleas KaramoutsiosLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0003-4311-7957
Emmanouil D OikonomouHuman Computer Interaction Laboratory, Department of Informatics and Telecommunications, University of Ioannina, 47100 Arta, Greece.ORCID 0009-0004-9227-1365
Chrysoula Chrysa VoidarouLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0002-8035-1710
Lampros HatzizisisLaboratory of Animal Science, Nutrition and Biotechnology, School of Agriculture, University of Ioannina, 47100 Arta, Greece.
Konstantina FotouLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.
Konstantina NikolaouLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.
Evangelia GouvaLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.
Evangelia GkizaP.G. Nikas SA, Department of Regulatory Affairs & Quality Assurance, Agios Stefanos, 14565 Attica, Greece.
Nikolaos GiannakeasHuman Computer Interaction Laboratory, Department of Informatics and Telecommunications, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0002-0615-783X
Ioannis SkoufosLaboratory of Animal Science, Nutrition and Biotechnology, School of Agriculture, University of Ioannina, 47100 Arta, Greece.
Athina TzoraLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0003-2615-7068

Funding

Co-financed by the European Agricultural Fund for Rural Development (EARFD) of the European Union and Greek national funds within the framework of the Rural Development Program of Greece 2014-2020 M16SYN2-00267
6 · The paper itself

Abstract

Milk's biological origin determination, including its adulteration and authenticity, presents serious limitations, highlighting the need for innovative advanced solutions. The utilisation of proteomic technologies combined with personalised algorithms creates great potential for a more comprehensive approach to analysing milk samples effectively. The current study presents an innovative approach utilising proteomics and neural networks to classify and distinguish bovine, ovine and caprine milk samples by employing advanced machine learning techniques; we developed a precise and reliable model capable of distinguishing the unique mass spectral signatures associated with each species. Our dataset includes a diverse range of mass spectra collected from milk samples after MALDI-TOF MS (Matrix-assisted laser desorption/ionization-time of flight mass spectrometry) analysis, which were used to train, validate, and test the neural network model. The results indicate a high level of accuracy in species identification, underscoring the model's potential applications in dairy product authentication, quality assurance, and food safety. The current research offers a significant contribution to agricultural science, providing a cutting-edge method for species-specific classification through mass spectrometry. The dataset comprises 648, 1554, and 2392 spectra, represented by 16,018, 38,394, and 55,055 eight-dimensional vectors from bovine, caprine, and ovine milk, respectively.

Indexed as

food quality assurancesmachine learningMALDI-TOF MSmass spectrometryneural networksproteomicsruminant milk

Identifiers

PMID40407488
PMCPMC12101317

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.