Evidence map›Paper›PMID 40407533›Full record

ArticleJournal of xenobiotics2025

Effect of Retinoic Acid on the Cerebral Vasculature: Analysis of the Vasoactive Response of Smooth Muscle Cells in Normal and Ischemic Contexts.

Manuel R Pouso, Emanuel Farinha, Henrique E Costa, Margarida Lorigo, Graça Baltazar, Elisa Cairrao

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Relationships Between Environmental Toxicology and Human Health.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuel R PousoHealth Sciences Research Centre (CICS), University of Beira Interior (UBI), 6200-506 Covilha, Portugal.
Emanuel FarinhaHealth Sciences Research Centre (CICS), University of Beira Interior (UBI), 6200-506 Covilha, Portugal.ORCID 0000-0002-1728-2855
Henrique E CostaHealth Sciences Research Centre (CICS), University of Beira Interior (UBI), 6200-506 Covilha, Portugal.ORCID 0000-0002-5358-9889
Margarida LorigoHealth Sciences Research Centre (CICS), University of Beira Interior (UBI), 6200-506 Covilha, Portugal.ORCID 0000-0002-4752-6398
Graça BaltazarHealth Sciences Research Centre (CICS), University of Beira Interior (UBI), 6200-506 Covilha, Portugal.ORCID 0000-0002-7942-0432
Elisa CairraoHealth Sciences Research Centre (CICS), University of Beira Interior (UBI), 6200-506 Covilha, Portugal.ORCID 0000-0002-4823-5701

Funding

European Regional Development Fund Project Centro-01-0145-FEDER-000019-C4-Centro de Competências em Cloud ComputingFCT - Fundação para a Ciência e a Tecnologia, I.P. DOI 10.54499/2020.06616.BDFCT - Fundação para a Ciência e a Tecnologia, I.P. DOI 10.54499/UIDB/00709/2020FCT - Fundação para a Ciência e a Tecnologia, I.P. DOI 10.54499 /UIDP/00709/2020
6 · The paper itself

Abstract

Retinoic acid (RA), a vitamin A derivative, has been shown to prevent the development of neurological disorders by ensuring the integrity of the physiological structure of the neurovascular unit and regulating the physiological cell's function. After an ischemia event, RA reduces the effects of blood-brain barrier disruption by blocking the apoptotic signaling pathway. However, the effect of RA on smooth muscle cells (SMCs), which are crucial to maintaining blood perfusion, has never been investigated. This study aimed to evaluate the effect of RA on the vasoactive response of middle cerebral artery SMCs in normal and ischemic contexts (O

Indexed as

cerebral blood flowmiddle cerebral arteryneurovascular diseasesneurovascular unitretinoids

Identifiers

PMID40407533
PMCPMC12101329

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.