ArticleNano letters2025
Acoustic Field Enabled Polymeric Nanoparticle Deposition onto Vessel Walls for Enhanced Drug Delivery.
Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
Polymeric nanoparticles (NPs) are promising tools for transporting and localizing therapeutics with intravenous delivery. Targeting these vehicles to specific tissue sites is challenging. Here, we investigate the use of low-frequency acoustic fields to drive polymeric NPs from circulating blood onto blood vessel walls by using concepts of elastic material deformation. By varying the shear flow rate and duration of acoustic field exposure, we achieved a 1000-fold increase in NP fluorescence intensity on vascular tissue compared with no acoustic field at a flow rate of 2 m/min. Interestingly, we found that acoustic-field-enhanced NP deposition is independent of NP surface chemistry. We also showcase a 100-fold increase in the area of fluorescence detected following NP delivery to an intact,
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