Evidence map›Paper›PMID 40407591›Full record

ArticleNon-coding RNA2025

Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer.

Valeria Pecci, Melissa Borsa, Aurora Aiello, Sara De Martino, Luca Cis, Cristian Ripoli, Dante Rotili, Francesco Pierconti, Francesco Pinto, Claudio Grassi and 3 more

Abstract read
In one paragraph

Article in Non-coding RNA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valeria PecciDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0001-9170-3593
Melissa BorsaDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0009-0005-8722-4350
Aurora AielloNational Research Council (CNR)-IASI, 00185 Rome, Italy.ORCID 0000-0002-8303-1528
Sara De MartinoNational Research Council (CNR)-IASI, 00185 Rome, Italy.ORCID 0000-0002-6226-4090
Luca CisDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Cristian RipoliFondazione "Policlinico Universitario A. Gemelli IRCCS", 00168 Rome, Italy.ORCID 0000-0002-5315-0163
Dante RotiliDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, 00185 Rome, Italy.ORCID 0000-0002-8428-8763
Francesco PiercontiFondazione "Policlinico Universitario A. Gemelli IRCCS", 00168 Rome, Italy.
Francesco PintoFondazione "Policlinico Universitario A. Gemelli IRCCS", 00168 Rome, Italy.
Claudio GrassiFondazione "Policlinico Universitario A. Gemelli IRCCS", 00168 Rome, Italy.ORCID 0000-0001-7253-1685
Carlo GaetanoLaboratory of Epigenetics, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0002-5238-1832
Antonella FarsettiNational Research Council (CNR)-IASI, 00185 Rome, Italy.ORCID 0000-0002-8603-7925
Simona NanniDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Funding

Italian Association for Cancer Research AIRC under IG 2019-ID 22858 project-PI Nanni SimonaItalian Ministry of Education, University and Research EU funding within the MUR PNRR "National Center for Gene Therapy and Drugs based on RNA Technology" (Project no. CN00000041 CN3 RNA) to AFItalian Ministry of Education, University and Research PRIN2022WWY7AA to APMinistero della Salute Regione Lombardia, progetto "Immunhub" to C.GaMinistero della Salute RF-2019-12370266 to APMinistero della Salute Ricerca Corrente - Progetto di Rete Aging " Next Generation Promising " Ricerca Corrente 2022 to CGa
6 · The paper itself

Abstract

BACKGROUND/

objectivesMetastatic prostate cancer (PCa) remains a major clinical challenge with limited therapeutic options. The long non-coding RNA

methods

resultsBET inhibition significantly reduced the expression of β4 integrin and E-cadherin and cell proliferation in both basal conditions, and following

conclusionsOur study demonstrates that BRD4 epigenetically regulates the

Indexed as

epigeneticslong non-coding RNAmetastatic programtranscription regulation

Identifiers

PMID40407591
PMCPMC12101203

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.