Evidence map›Paper›PMID 40407806›Full record

ArticleSoft matter2025

Gelation behavior of short protected peptides in organic medium.

Thomas M FitzSimons, Israt Jahan Duti, Nathaniel Conrad, Paridhi Agrawal, Alexandria Niemoeller, Emily Guinn, Jingyao Wang, Anastasiia Vasiukhina-Martin, Adrianne M Rosales

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Soft matter, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas M FitzSimonsMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, USA. arosales@che.utexas.edu.ORCID http://orcid.org/0000-0001-7316-475X
Israt Jahan DutiMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, USA. arosales@che.utexas.edu.ORCID http://orcid.org/0009-0001-9718-8198
Nathaniel ConradMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, USA. arosales@che.utexas.edu.ORCID http://orcid.org/0000-0002-2330-2250
Paridhi AgrawalEli Lilly and Company, Indianapolis, USA.ORCID http://orcid.org/0000-0002-8290-3275
Alexandria NiemoellerEli Lilly and Company, Indianapolis, USA.ORCID http://orcid.org/0009-0001-4900-7102
Emily GuinnEli Lilly and Company, Indianapolis, USA.ORCID http://orcid.org/0000-0002-9974-3458
Jingyao WangEli Lilly and Company, Indianapolis, USA.ORCID http://orcid.org/0000-0002-3511-4724
Anastasiia Vasiukhina-MartinEli Lilly and Company, Indianapolis, USA.
Adrianne M RosalesMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, USA. arosales@che.utexas.edu.ORCID http://orcid.org/0000-0003-0207-7661

Funding

Expanding the Functionality of Engineered Extracellular MatricesR35GM138193 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ROSALES, ADRIANNE · 2020 to 2024
$1.9M
NIGMS NIH HHS R35 GM138193
6 · The paper itself

Abstract

Peptide gelators have been widely explored in aqueous systems due to their prevalence in biological and medical applications. However, gelation behavior of peptides is less understood in organic medium, despite the extensive use of organic solvents in solid phase peptide synthesis, hybrid synthesis protocols, and the formation and application of organogels. Here, peptides with a short aqueous gelator sequence, lysine-tyrosine-phenylalanine or KYF, were investigated for the ability to form gels in dichloromethane (DCM) when their side groups are protected. Protected KYF-containing peptides formed gels in DCM at similar concentrations to deprotected KYF peptides in water. Structural characterization

Indexed as

OligopeptidesPeptidesGelsMethylene ChlorideRheologySolventsWaterGelsMethylene ChlorideOligopeptidesPeptidesSolventsWater

Identifiers

PMID40407806
PMCPMC12101513

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.