ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Stromal-Like Cells and Retinal Pigment Epithelium Modulate Choroidal Sprouting Through Galectin-1-Dependent and Independent Pathways.
Magali E Ridano, Christin Hanke-Gogokhia, Guillermo L Lehmann, Paulo S Caceres, Maria V Vaglienti, Danilo Ceschin, Ryan Schreiner, Diego O Croci, Carlos Torroja-Fungairiño, Enrique Rodriguez-Boulan and 3 more
Abstract read
In one paragraphArticle in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Magali E RidanoDepartamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Christin Hanke-GogokhiaDepartment of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine, New York, New York, USA.
Guillermo L LehmannDepartment of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine, New York, New York, USA.
Paulo S CaceresDepartment of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine, New York, New York, USA.
Maria V VaglientiDepartamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Danilo CeschinInstituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Córdoba, Argentina.
Ryan SchreinerDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-7457-6606 Diego O CrociLaboratorio de Inmunopatología, Instituto de Histología y Embriología "Dr. Marío H. Burgos" (IHEM), Facultad de Exactas y Naturales, CONICET, Universidad Nacional de Cuyo, Mendoza, Argentina.ORCID https://orcid.org/0000-0002-8623-0645 Carlos Torroja-FungairiñoBioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Ignacio BenedictoDepartment of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine, New York, New York, USA.
Funding
UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS MalignanciesU54CA221208 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI COSO, OMAR ADRIAN, RAMOS, JUAN CARLOS · 2017 to 2022
$3.3Magenciaidiar | Fondo para la Investigación Científica y Tecnológica (FONCYT) 01586agenciaidiar | Fondo para la Investigación Científica y Tecnológica (FONCYT) 1314agenciaidiar | Fondo para la Investigación Científica y Tecnológica (FONCYT) 2440Foundation for the National Institutes of Health (FNIH) R01 EY08531MEC | Agencia Estatal de Investigación (AEI) 033805-IMEC | Agencia Estatal de Investigación (AEI) 137111OA-I00NCI NIH HHS U54 CA221208
6 · The paper itselfAbstract
Outer retinal function depends on two supporting tissues: the retinal pigment epithelium (RPE) and the choroid. Limited molecular information is available on the intercellular networks that sustain RPE/choroid tissue in both healthy and pathological states. Galectin-1 (Gal1), a β-galactoside-binding lectin, has recently emerged as a key regulator of angiogenesis and a potential therapeutic target in vascular pathologies, including age-related macular degeneration. Here, we studied the expression of Gal1 in the outer retina and its regulatory role in the RPE/choroid under physiological and pathological conditions. Our findings indicate that Gal1 is predominantly associated with stromal cells in the RPE/choroid. In Gal1-deficient (Lgals1
Indexed as
ChoroidGalectin 1Retinal Pigment EpitheliumStromal CellsAnimalsChoroidal NeovascularizationHumansMacular DegenerationMiceMice, Inbred C57BLMice, KnockoutGalectin 1age‐related macular degenerationangiogenesisGalectin‐1hypoxiainflammationocular physiological processes
Identifiers
PMID40407849
PMCPMC12229269
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