ArticleDiscover oncology2025
Exploring the genetic causal inference between plasma lipidome and lung carcinoma: a bidirectional mendelian randomization study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
backgroundClinical observational studies have highlighted differences in plasma lipid profiles between lung carcinoma patients and healthy individuals. However, the causal relationship underlying these differences remains unclear. This study aims to investigate the bidirectional causal relationship between 179 plasma lipids and lung carcinoma.
methodsA bivariate two-sample Mendelian randomization (MR) study was conducted using data from public genome-wide association studies (GWAS). The primary analytical technique employed was the inverse variance weighting method (IVW), with MR-Egger, weighted-median, and weighted mode as supplementary methods. Sensitivity analyses including Cochran's Q test and MR-Egger intercept test were performed to ensure the robustness of the results.
resultsMendelian randomization analysis revealed positive associations between levels of certain plasma lipidome-Sterol ester 27:1/20:5 levels (OR 1.162, 95% confidence interval (CI) 1.077-1254, P 1.15e
conclusionOur study reveals the causal relationship between plasma lipidome and lung cancer, provides preliminary genetic evidence, and provides a new idea for understanding the pathogenesis of lung cancer and finding promising therapeutic targets.
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