ArticleStem cell reports2025
Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue.
Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adipose Progenitor Cells in Thermogenesis and Metabolic Regulation.Physiology (Bethesda, Md.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancing energy utilization by increasing the number or activity of beige adipocytes has the potential to be of therapeutic benefit for a broad range of metabolic disorders. However, knowledge gaps in our understanding of the mouse versus human developmental origins of beige fat have inhibited the generation of robust preclinical models, leaving a barrier to the success of therapies. Here, we report that a distinct inguinal beige adipose tissue (ibAT) depot lineage traces to the same Prx1+ cell origins as inguinal white adipose tissue (iWAT) but maintains higher thermogenic activity and capability during aging. We discovered that ibAT has the morphological appearance of human supraclavicular brown adipose tissue (scBAT) and, importantly, conserved molecular markers and developmental origins with human scBAT. Our findings reveal a distinct mouse beige adipose tissue depot and provide a preclinical model of human beige adipose tissue development and maintenance.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.