ReviewNeuroscience and biobehavioral reviews2025
Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers.
Review in Neuroscience and biobehavioral reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effects of nonpharmacological manipulations and repeated xanomeline treatment on methamphetamine-vs-food choice in Sprague Dawley and Long Evans rats.Drug and alcohol dependence · 2026Article
- Utility of substance-free alternatives in treating and preventing harmful substance use: A narrative review of the translational research spectrum.Drug and alcohol dependence reports · 2025Review
- Assessing behavioral reallocation after acute environmental manipulations using an asymmetric cocaine versus sucrose choice task in male and female rats.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Substance use disorders are increasingly being conceptualized as behavioral misallocation disorders; however, the neurobiological determinants of this behavioral misallocation are poorly understood. Cocaine use disorder (CUD) develops as a result of behavior being disproportionally directed towards the procurement and use of cocaine at the expense of behaviors maintained by more adaptive, nondrug reinforcers (i.e., job, family). Preclinical cocaine-vs-nondrug reinforcer choice procedures are uniquely positioned to 1) elucidate the biological mechanisms of drug and nondrug reinforcement and 2) inform the development of effective pharmacological and behavioral CUD therapies. Accordingly, this review addresses the existing preclinical literature regarding the economic substitutability and mesolimbic dopaminergic mechanisms underlying cocaine self-administration in the context of three different concurrently available nondrug reinforcers: food, social interaction, and electric foot shock (a negative reinforcer). The manuscript focuses on how the existing cocaine-vs-nondrug reinforcer choice literature guides future research directions to facilitate advances in understanding of CUD from both a neuroscience and translational research perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.