Evidence map›Paper›PMID 40409691›Full record

ReviewTransplantation and cellular therapy2025

NIH Chronic Graft-Versus-Host Disease Consensus Conference 2025 Update.

Stephanie J Lee, Kirsten M Williams, Stefanie Sarantopoulos, Carrie L Kitko, Corey Cutler, Joseph Pidala, Geoffrey R Hill, Zachariah DeFilipp, Hildegard T Greinix, Daniel Wolff and 4 more

Abstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplantation and cellular therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. [First-line treatment for chronic graft-versus-host disease: a real-world study].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stephanie J LeeClinical Research Division and Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington. Electronic address: sjlee@fredhutch.org.
Kirsten M WilliamsAflac Blood and Cancer Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta Georgia.
Stefanie SarantopoulosDivision of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Carrie L KitkoVanderbilt University Medical Center, Nashville, Tennessee.
Corey CutlerDivision of Transplantation and Cellular Therapy, Dana-Farber Cancer Institute, Boston, Massachusetts.
Joseph PidalaDepartment of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Geoffrey R HillClinical Research Division and Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Zachariah DeFilippHematopoietic Cell Transplant and Cellular Therapy Program, Massachusetts General Hospital, Boston, Massachusetts.
Hildegard T GreinixDivision of Hematology, Medical University, Graz, Austria.
Daniel WolffDepartment of Internal Medicine III, University Hospital Regensburg, Germany.
Sophie PaczesnyHollings Cancer Center, Department of Immunology, Medical University of South Carolina, Charleston, South Carolina.
Geoffrey D E CuvelierPediatric Oncology and Transplantation, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
Kirk R SchultzBC Children's Hospital Research Institute and University of BC, Vancouver, British Columbia, Canada.
Steven Z PavleticNational Cancer Institute, Center for Cancer Research, Immune Deficiency Cellular Therapy Program, National Institutes of Health, Bethesda, Maryland. Electronic address: pavletics@outlook.com.

Funding

Improving Outcomes Assessment in Chronic GVHDR01CA118953 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEE, STEPHANIE J · 2011 to 2025
$8.3M
Biologic correlatives of chronic GVHD onsetU01CA236229 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEE, STEPHANIE J · 2019 to 2023
$3.9M
NCI NIH HHS R01 CA118953NCI NIH HHS U01 CA236229
6 · The paper itself

Abstract

In 2020, the third NIH Consensus Development Project on Criteria for Chronic Graft-versus-Host Disease (GVHD) Clinical Trials was held with the goals of identifying gaps in understanding, prevention and treatment of chronic graft-versus-host disease (GVHD) and making actionable recommendations that would advance the field. An interim meeting was held in October 2024 to review progress on the 2020 recommendations. Each group was charged with reviewing their previous recommendations, assessing whether the field is on track to eventually achieve the goals, and considering whether recommendations should be modified in light of new data or insufficient progress. This manuscript summarizes the Working Groups' reports and helps define the research agenda for future studies in chronic GVHD. Overall, modest progress has been made on most initiatives. Some studies in progress will address key recommendations and results are eagerly anticipated.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationChronic DiseaseHumansNational Institutes of Health (U.S.)United StatesAllogeneic transplantationBIOMARKERSChronic GvHDCONFERENCETREATMENT

Identifiers

PMID40409691
PMCPMC12354025

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.