ArticleNature communications2025
The health impacts and genetic architecture of food liking in cardio-metabolic diseases.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Genetic Variants Influencing Taste Perception and Food Preferences: Current Evidence.Nutrients · 2026Review
- Precision Nutrition in Type 2 Diabetes Prevention Through Molecular Nutrigenomic and Epigenetic Modulation of Insulin Signaling and Glucose Metabolism.International journal of molecular sciences · 2026Review
- Comments to the editor: Opinions on "Associations between dietary intake and pancreatic disease: a mendelian randomization study".International journal of surgery (London, England) · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565-977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes. Notably, we found three genetic links: diet-fizzy-drinks with heart-failure, bacon with type-2-diabetes, and lentils/beans with type-2-diabetes, identifying 54 pleiotropic single-nucleotide-variants, impacting both phenotypes. Our data show the diet-fizzy-drinks and heart-failure link maybe not direct, as diet-fizzy-drinks liking correlates with sweet food consumption and shares variants linked to BMI, adiposity, platelet count and cardio-metabolic traits. The pleiotropic single-nucleotide-variants map to 251 tissue-specific genes, with four showing high druggability potential, highlighting personalized dietary strategies for cardio-metabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.