Evidence map›Paper›PMID 40410195›Full record

ArticleScientific reports2025

Phytochemical, biological, DFT, and molecular docking evaluation of Euphorbia paralias.

Abdullah I Kamel, Safa A Badawy, Mamdouh Abdel-Mogib, Ahmed Ramadan El-Rokh

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abdullah I KamelChemistry Department, Faculty of Science, New Mansoura University, Mansoura, Egypt. Abdullah.kamel@nmu.edu.eg.ORCID http://orcid.org/0009-0007-4834-299X
Safa A BadawyChemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Mamdouh Abdel-MogibChemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Ahmed Ramadan El-RokhPlant Protection Research Institute, Agricultural Research Center, Giza, 12618, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to bridge the knowledge gap in the unclear previous studies of the molecular processes that cause the biological activities of Euphorbia paralias by integrating phytochemical analysis with quantum chemical calculations and molecular docking investigations, providing unprecedented insights into the therapeutic potential of its chemical constituents. Seven important flavonoids were isolated and identified using spectroscopic techniques, and 34 and 13 additional compounds were identified via GC/MS analysis of the hexane and chloroform fractions, respectively. The crude methanol extract, some fractions, and isolated compounds were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria. Among the tested constituents, β-sitosterol-3-O-β-D-glucoside 1, kaempferol-3-O-α-D-arabinopyranoside 4, and genistein-8-β-C-glucoside 6, as well as the chloroform and ethyl acetate fractions, demonstrated notable broad-spectrum antibacterial activity. The insecticidal activities of the butanol fraction and a combination of genistein-4'-O-β-D-glucopyranoside 2 and quercetin-3-O-β-D-glucoside 3 significantly inhibited Aphis gossypii and Amrasca biguttula, with LC

Indexed as

EuphorbiaMolecular Docking SimulationPhytochemicalsPlant ExtractsAnti-Bacterial AgentsDensity Functional TheoryFlavonoidsGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsAnti-Bacterial AgentsFlavonoidsPhytochemicalsPlant ExtractsAntibacterial activityBioactivityEuphorbia paraliasFlavonoid glycosidesInsecticidal activityMolecular dockingNatural productsQuantum chemical analysis (DFT)

Identifiers

PMID40410195
PMCPMC12102368

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.