ArticleScientific reports2025
Brain basis for physical activity levels mediate beta Inhibition to improve cognitive function in elderly based on multimodality monitoring.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nonlinear dose-response of mind-body exercise in older adults with mild cognitive impairment: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Resting state EEG mediates the association between physical activity and cognitive function in cognitively impaired elderly.Scientific reports · 2026Article
- Whey protein supplementation and exercise in older adults: a narrative review of potential effects on muscle-brain axis, physical function, and related outcomes.Frontiers in nutrition · 2026Review
- The impact of 24-h activity patterns on executive function in older adults with chronic diseases: analysis of the isotonic substitution effect.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ameliorative effect of regular physical activity (PA) on cognitive function (CF) in older adults has been demonstrated. However, there are differences in the effects of different levels of PA on CF over time. To provide a more efficient exercise prescription for older adults, we compared differences in CF with neural mechanisms in individuals with different weekly activity levels. In this study, 68 older adults (n = 68, M = 47, F = 21, Age = 62.43 ± 4.36) were categorized according to the International Physical Activity Questionnaire (IPAQ) into high volume PA group (HG) (MET-min/week = 1516.64 ± 138.68), moderate volume PA group (MG) (MET-min/week = 1248.02 ± 119.86), and control group (MET-min/week = 1248.02 ± 119.86). 1516.64 ± 138.68), moderate volume PA group (MG) (MET-min/week = 1248.02 ± 119.86), and control group (MET-min/week = 846.78 ± 97.53). Differences in Stop Signal, Stroop, and 2-Back were compared among the three groups. Electroencephalogram (EEG), event-related potential (ERP), and magnetic resonance imaging (MRI) features were also observed. The results showed that for CF, 2-Back with Stroop was significantly higher in MG versus HG than in CG (F = 121.45, P < 0.01; F = 88.74, P < 0.01), and the opposite was true for response (F = 236.83, P < 0.01; F = 187.64, P < 0.01). Stroop was higher in HG than in MG (F = 38.78, P = 0.037) and Stop Signal was higher than in CG (F = 52.03, P < 0.01). In terms of EEG, the alpha band share of HG was higher than CG at rest (F = 41.34, P = 0.040) and the opposite in work (F = 25.67, P = 0.046). Although the remaining results were not statistically significant, PA levels were inversely proportional to resting midrange-band β (CG = 8.98 ± 1.02, MG = 8.07 ± 0.76, HG = 8.13 ± 0.88), and positively proportional to midrange and high-band β in WORK (midrange β: CG = 12.41 ± 2.29, MG = 12.98 ± 3.04, HG = 13.21 ± 2.85; high β: CG = 6.76 ± 2.23, MG = 7.35 ± 1.96, HG = 7.91 ± 2.3). In ERP, the latencies of N200, P300, and N450 were significantly shorter than those of CG in HG (F = 44.63, P = 0.041; F = 29.69, P = 0.045; F = 76.48, P < 0.01), and only N450 was shorter than that of CG in MG (F = 59.62, P < 0.01). On MRI, HG had Middle Frontal Gyrus (MFG) (HG > CG, voxel = 188, t = 3.72), Right Superior Frontal Gyrus (RSFG) (HG > CG, voxel = 238, t = 4.07), Left Cingulate (HG > CG, voxel = 343, t = 4.36), and Left Supplementary Motor Area (LSMA) (HG > CG, voxel = 343, t = 4.36) were activated more than CG. MFG (MG > CG, voxel = 172, t = 3.56), LSMA (MG > CG, voxel = 331, t = 4.28), and PHG (MG > CG, voxel = 204, t = 3.35) were activated more than CG. It was concluded that PA significantly enhanced CF in older adults, and that high volume PA was more effective than moderate volume. Specifically, VPA was found to be significantly more effective than MPA and LPA in enhancing individuals' inhibition function, cognitive flexibility, working memory, and reaction speed. This may be attributed to the increase in ERP amplitude with shorter latency and greater gray matter density in frontal and temporal lobe regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.