ReviewDiscover oncology2025
Recent advances in understanding the role of Wnt5a in prostate cancer and bone metastasis.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Assessment of miRNA 106a-5p and 375-3p Expression in the Context of the Wnt/β-Catenin Pathway-Comparison of Prostate Adenocarcinoma and Benign Prostatic Hyperplasia Tissues.International journal of molecular sciences · 2025Article
- From Worms to Tumors: Conserved Strategies of Cellular Arrest and Survival Governing Dormancy.Cancer research · 2025Review
- Hypoxia-Driven Extracellular Vesicles Promote Pro-Metastatic Signalling in LNCaP Cells via Wnt and EMT Pathways.Biology · 2025Article
- Elucidating the multiscale mechanisms and therapeutic targets of caffeic acid in gastric cancer: a synergy of computational and experimental approaches.Frontiers in molecular biosciences · 2025Article
- Unleashing Wnts: Wnt Ligands Fuel Cancer Spread.Journal of cancer biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer (PCa) is a leading cause of cancer-related mortality in men, with a high propensity for bone metastasis that significantly impairs patient quality of life. The Wnt5a signaling pathway plays a pivotal role in the progression and metastasis of PCa. Wnt5a can act as both an oncogene and a tumor suppressor, highlighting its complex and context-dependent functions. In PCa, Wnt5a promotes tumor progression through mechanisms such as epithelial-mesenchymal transition (EMT) and interaction with androgen receptor (AR) signaling. Conversely, Wnt5a can induce dormancy in bone-metastatic PCa cells via the ROR2/SIAH2 axis, inhibiting the Wnt/β-catenin pathway. Understanding the dual roles of Wnt5a in PCa and bone metastasis is crucial for elucidating the underlying mechanisms of disease progression and identifying potential therapeutic targets. This review focuses on the current understanding of Wnt5a's role in PCa and bone metastasis, emphasizing its significance in tumor biology and clinical management.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.