ArticleBMC public health2025
Proteinuria is risk factor for abdominal aortic aneurysm: a nationwide population-based study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProteinuria is a well-known risk factor for cardiovascular disease. However, the impact of proteinuria on abdominal aortic aneurysm (AAA) remains unclear. In this study, we aimed to investigate the association between proteinuria and AAA. To assess the correlation between proteinuria measured by the urine dipstick test (UDT) and the risk of AAA by using nationwide population cohort data.
methodsThis retrospective cohort study used data from the Korean National Health Insurance database for individuals who had health check-ups in 2009. Incident AAA was ascertained through the end of 2019. The study population was classified into the following five groups based on the UDT result: negative; trace; 1+; 2+; and ≥ 3+. The primary endpoint was newly developed AAA during the study period.
resultsA total of 9,938,329 patients were enrolled. During a median follow-up of 9.3 years (interquartile range 9.1-9.6), 20,760 (0.2%) AAA events were identified, and the incidence rates of AAA were 2.21, 2.55, 4.20, 5.77 and 7.49 per 10,000 per year in the negative, trace, 1+, 2 + and 3 + ≤ proteinuria groups, respectively, compared with those without proteinuria (P <.001). There was a positive correlation between the degree of proteinuria and the risk of AAA, which was consistent regardless of all estimated glomerular filtration rate categories.
conclusionProteinuria as measured by the UDT was strongly associated with AAA and acted as an independent risk factor. These findings suggest that proteinuria may serve as a potential marker for identifying individuals at higher risk of AAA.
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