ArticleBMC ophthalmology2025
Optical coherence tomography angiography in non-alcoholic fatty liver disease: is it a disease affecting the microvascular system??
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate retinal thickness and vascular structure in patients with non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography (OCT) and OCT angiography (OCTA) and to compare the results with healthy controls.
methodThe medical records of NAFLD patients were retrospectively reviewed. Macular thickness (MT) and peripapillary retinal nerve fibre layer (pRNFL) thickness were assessed. The vessel density (VD) of Superficial Capillary Plexus (SCP), Deep Capillary Plexus (DCP), foveal avascular zone (FAZ) area, FAZ circularity index (CI), and FAZ perimeter were also recorded.
resultsThe study included 64 patients with NAFLD and 64 healthy controls. Mean MT and pRNFLT were similar between groups. The study group showed a significant reduction in VD-DCP compared to the control group (36.0 ± 5.2 vs. 38.5 ± 4.1, p < 0.001). Total FAZ area was greater in the study group than in the control group (0.42 ± 0.10 vs. 0.33 ± 0.12mm2, p < 0.001). FAZ CI also differed between groups (0.47 ± 0.08 vs. 0.53 ± 0.08, p < 0.001). Enlarged FAZ area and decreased VD-DCP were significantly associated with NAFLD severity.
conclusionIndividuals with NAFLD have certain changes in the retinal microvasculature, including reduced VD-DCP, an increased FAZ area, and a decreased of FAZ CI. The variations in VD-DCP and FAZ area exhibit discrepancies according to the disease grade. There are some limitations, including its retrospective nature, the small number of participants, the lack of analysis of the peripapillary area, and the lack of examination of longitudinal changes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.