Evidence map›Paper›PMID 40410872›Full record

ReviewMicrobiome2025

Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes.

Robert Heyer, Maximilian Wolf, Dirk Benndorf, Sergio Uzzau, Jana Seifert, Lucia Grenga, Martin Pabst, Heike Schmitt, Bart Mesuere, Tim Van Den Bossche and 11 more

Abstract readReviewVideo-Audio Media
In one paragraph

Review in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Robert HeyerMultidimensional Omics Analyses Group, Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Bunsen-Kirchhoff-Straße 11, 44139, Dortmund, Germany. robert.heyer@ISAS.de.
Maximilian WolfMultidimensional Omics Analyses Group, Faculty of Technology, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Dirk BenndorfBioprocess Engineering, Otto-Von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Sergio UzzauDepartment of Biomedical Sciences, University of Sassari, 07100, Sassari, Italy.
Jana SeifertInstitute of Animal Science, University of Hohenheim, Emil-Wolff-Str, Stuttgart, Germany.
Lucia GrengaDépartement Médicaments Et Technologies Pour La Santé (DMTS), Université Paris-Saclay, CEA, INRAE, SPI, Bagnols-Sur-Cèze, France.
Martin PabstDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Heike SchmittDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Bart MesuereDepartment of Applied Mathematics, Computer Science and Statistics, Ghent University, 9000, Ghent, Belgium.
Tim Van Den BosscheVIB - UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.
Sven-Bastiaan HaangeDepartment of Molecular Toxicology, Helmholtz-Centre for Environmental Research - UFZ GmbH, Permoserstrasse 15, 04318, Leipzig, Germany.
Nico JehmlichDepartment of Molecular Toxicology, Helmholtz-Centre for Environmental Research - UFZ GmbH, Permoserstrasse 15, 04318, Leipzig, Germany.
Mariagrazia Di LucaDepartment of Biology, University of Pisa, 56127, Pisa, Italy.ORCID 0000-0002-0688-034X
Manuel FerrerInstituto de Catalisis y Petroleoquimica (ICP), CSIC, 28049, Madrid, Spain.ORCID 0000-0003-4962-4714
Sergio Serrano-VillarDepartment of Infectious Diseases, Hospital Universitario Ramon y Cajal, Instituto de Investigación Sanitaria Ramón y Cajal (IRYCIS), CIBER de Enfermedades Infecciosas, Madrid, Spain.ORCID 0000-0002-5447-3554
Jean ArmengaudDépartement Médicaments Et Technologies Pour La Santé (DMTS), Université Paris-Saclay, CEA, INRAE, SPI, Bagnols-Sur-Cèze, France.
Helge B BodeDepartment of Natural Products in Organismic Interactions, Max-Planck-Institut for Terrestrial Microbiology, Karl-Von-Frisch-Str. 10, 35043, Marburg, Germany.
Patrick HellwigBioprocess Engineering, Otto-Von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Catherine Robbe MasselotUniversité de Lille, CNRS, UMR, 8576 - UGSF, Lille, France.
Renaud LéonardUniversité de Lille, CNRS, UMR, 8576 - UGSF, Lille, France.
Paul WilmesLuxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-Sur-Alzette, Luxembourg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One Health seeks to integrate and balance the health of humans, animals, and environmental systems, which are intricately linked through microbiomes. These microbial communities exchange microbes and genes, influencing not only human and animal health but also key environmental, agricultural, and biotechnological processes. Preventing the emergence of pathogens as well as monitoring and controlling the composition of microbiomes through microbial effectors including virulence factors, toxins, antibiotics, non-ribosomal peptides, and viruses holds transformative potential. However, the mechanisms by which these microbial effectors shape microbiomes and their broader functional consequences for host and ecosystem health remain poorly understood. Metaproteomics offers a novel methodological framework as it provides insights into microbial dynamics by quantifying microbial biomass composition, metabolic functions, and detecting effectors like viruses, antimicrobial resistance proteins, and non-ribosomal peptides. Here, we highlight the potential of metaproteomics in elucidating microbial effectors and their impact on microbiomes and discuss their potential for modulating microbiomes to foster desired functions.

Indexed as

BacteriaMicrobiotaOne HealthProteomicsAnimalsHumansVirulence FactorsVirulence FactorsBacteriophagesMetaproteomicsMicrobial communityMicrobial effectorsMicrobiome

Identifiers

PMID40410872
PMCPMC12100821

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.