ArticleDiabetology & metabolic syndrome2025
Association between eGDR and accelerated aging: the mediating role of ePWV.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association of estimated pulse wave velocity with non-alcoholic fatty liver disease in multiple cohorts.iScience · 2026Article
- Estimated pulse wave velocity and risk of cardiometabolic multimorbidity in middle-aged and older adults: a cohort study.BMC cardiovascular disorders · 2026Article
- Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross-Sectional Study.Health science reports · 2026Article
- Organ-Specific Regulation of Systemic Aging: Focus on the Brain, Skeletal Muscle, and Gut.Cells · 2026Review
- Nonlinear Association of Estimated Pulse Wave Velocity With Bone Health Outcomes: Evidence From the NHANES Database.International journal of endocrinology · 2026Article
- Article
- Association between estimated glucose disposal rate and diabetes mellitus incidence in middle-aged and elderly adults and development of predictive model: evidence from two prospective longitudinal studies.BMC endocrine disorders · 2025Article
- Association of estimated glucose disposition rate with aging acceleration and mortality risk in individuals with cardiovascular-kidney-metabolic syndrome: evidence from two large national population-based studies.Cardiovascular diabetology · 2025Article
- Association between the depression and cardiovascular risk in arthritis patients: a prospective cohort study from the CHARLS database.Frontiers in immunology · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study examines the association between estimated glucose disposal rate (eGDR) and accelerated aging in middle-aged and older adults, with a focus on the mediating role of estimated pulse wave velocity (ePWV).
methodsData from the 2011 wave of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed, including middle-aged and older participants. Biological age was estimated using the Klemera-Doubal method, and accelerated aging was defined as the difference between biological and chronological age. The eGDR was calculated based on waist circumference, hypertension status, and HbA1c levels, while ePWV was estimated using mean blood pressure and age. Logistic regression models assessed the relationship between baseline eGDR, ePWV, and accelerated aging, adjusting for confounders.
resultsA total of 8,529 participants (mean age 59.31 years) were included. A significant inverse association was found between eGDR and accelerated aging. Participants with the lowest eGDR quartile had an 81% higher risk of accelerated aging compared to those in the highest quartile (OR = 0.19, 95% CI 0.17-0.22, P < 0.001). Mediation analysis showed that ePWV mediated 12.90% of the relationship between eGDR and accelerated aging (95% CI 9.20%-16.60%).
conclusionReduced insulin sensitivity, indicated by low eGDR, is a significant risk factor for accelerated aging. Vascular aging, measured by ePWV, mediates part of this relationship. These findings highlight the importance of monitoring insulin sensitivity and vascular health to mitigate aging and age-related health risks.
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