ArticleThe Journal of dermatology2025
The Role of T-Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis.
Article in The Journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Changes in T-cell subsets and their association with disease severity in patients with alopecia areata.Turkish journal of medical sciences · 2026Article
- IL-15 in alopecia areata: the immune tolerance mechanistic insights and translational perspectives.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAcute diffuse and total alopecia (ADTA) is a variant of alopecia areata (AA) that lacks the typical patchy hair loss seen in classical AA and presents with an acute onset of diffuse hair loss. It has a favorable prognosis.
objectivesThe purpose of this study was to assess the role of T-helper (Th) 17 cells and regulatory T cells (Tregs) in the pathogenesis of ADTA and their relevance to the good prognosis of ADTA.
methodsTwenty-four patients with ADTA and 12 healthy controls were included. Scalp skin samples were obtained for quantitative polymerase chain reaction (qPCR) specific for Th17 cells and Treg-related cytokines. Serum cytokines associated with Th17 cells and Tregs were measured using enzyme-linked immunosorbent assays. Additionally, we performed immunostaining for Th17 cells and Tregs. The correlation of qPCR results, serum cytokine levels, and immunostaining results with clinical characteristics was examined.
resultsLesional IL-2, IL-10, and IL-23A levels were significantly higher in patients with ADTA than in controls. In the progressive stage, lesional IL-2, IL-13, and IL-23A levels were significantly increased compared to those in controls. Serum IL-15 levels were significantly lower in patients than in controls in the progressive stage. In the recovery stage, lesional IL-13 and IL-23A levels were significantly increased compared to those in controls. The ratios of Th17/CD4+ cells and Tregs/CD4+ cells surrounding hair follicles of the patients were 40.73% and 8.50%, respectively, according to immunostaining results.
conclusionsThe increased activity of Treg cells, suggested through IL-10 and IL-15, is a characteristic of ADTA that is distinct from AA. The increased function of Tregs may explain the favorable prognosis of ADTA. Follow-up studies focusing on Tregs, IL-10, and IL-15 are required.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.