ArticleJournal of cellular and molecular medicine2025
The Neurogenic Abnormities of Paraspinal Muscles Lead to Asymmetry of Fibre Types in Adolescent Idiopathic Scoliosis.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Extent of fatty infiltration in lumbar paraspinal muscles in adults with degenerative scoliosis: segmental differences in muscle involvement.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Pooled it
- Effect of exercise therapy on adolescent idiopathic scoliosis in mild to moderate: a systematic review and network meta-analysis.Frontiers in medicine · 2025Pooled it
- Lumbar muscle morphology and composition in adolescent idiopathic scoliosis: a magnetic resonance study.Spine deformity · 2026Article
- CT-Derived Paraspinal Muscle Asymmetry Is Associated with Deformity Severity in Adolescent Idiopathic Scoliosis: A Quantitative CT Study.Journal of clinical medicine · 2026Article
- Radiographic outcomes of stick-assisted manipulation in adolescent idiopathic scoliosis: a retrospective study of 57 patients.Frontiers in pediatrics · 2026Article
- Pathogenic mechanisms of adult degenerative scoliosis.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The aetiology of adolescent idiopathic scoliosis (AIS) is not clear, and may involve disorders in multiple systems. This study aims to perform the morphological and molecular analysis of neuromuscular junctions (NMJs) and explore the asymmetry of paraspinal muscles in AIS. We collected paraspinal muscles from AIS patients during surgery and also enrolled congenital scoliosis (CS) and non-scoliosis patients as controls. We performed immunofluorescence staining of NMJs for morphological analysis. Then, we extracted NMJs regions for further validation at the molecular level. We also explored the neurogenic abnormalities in the convex side and compared the asymmetry of paraspinal muscles. Morphological analysis of NMJs showed that the nerve terminal-related variables in the convex side were significantly decreased. The expression of denervation markers was increased in the synapse-rich regions. The expression of denervation markers in the convex paraspinal muscles was also significantly increased. Compared with CS and non-scoliosis patients, paraspinal muscles of AIS exhibited the transformation of fibre types, characterised by an increase in the proportion of type I fibres in the convex side. The phenomenon of fibre-type grouping was also noted, confirming the presence of neurogenic abnormalities. This study first investigated the morphological and molecular disorders of NMJs in the paraspinal muscles from AIS patients. We found that the neurogenic abnormalities existed in the convex side of the paraspinal muscle, which could lead to the conversion and grouping of fibre types. This resulted in an imbalance of bilateral paraspinal muscles and might be a potential driver of scoliosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.