Evidence map›Paper›PMID 40411624›Full record

ArticleJournal of clinical immunology2025

Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV.

Weiying Zhang, Alan F Scott, David W Mohr, Roxann Ingersoll, Peter E Shoucair, Jay H Bream, Tricia L Nilles, Hao Zhang, Yue Chen, Robbie B Mailliard and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weiying ZhangDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Baltimore, MD, 21205, USA.
Alan F ScottDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
David W MohrDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Roxann IngersollDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Peter E ShoucairDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jay H BreamDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Baltimore, MD, 21205, USA.
Tricia L NillesDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Baltimore, MD, 21205, USA.
Hao ZhangDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Baltimore, MD, 21205, USA.
Yue ChenDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Robbie B MailliardDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Joseph B MargolickDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Baltimore, MD, 21205, USA. jmargol1@jhu.edu.

Funding

Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Antigen-specific ‘kick and kill’ of the latent HIV reservoir using dendritic cellsR01AI152655 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robbie B Mailliard · 2022 to 2026
$3.2M
NHLBI NIH HHS U01 HL146201NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI152655NIAID NIH HHS U01 AI035042NIH HHS U01-AI035042NIH HHS U01-HL146201
6 · The paper itself

Abstract

A man living with HIV was found to lack expression of CD16A on his natural killer (NK) cells and monocytes. Genetic analysis revealed compound heterozygous deletion of FCGR3A, the gene encoding CD16A. The case's NK cells showed: (a) no antibody-dependent cell-mediated cytotoxicity and very low spontaneous cytotoxicity; (b) an immature phenotype marked by high expression of CD94, CD2, NKG2A, and NKG2D, and low expression of KIR2DL2 and CD57; (c) no expression of KIR3DL1 and very low expression of FcRγ; and (d) normal cytokine production. The case's monocytes and DCs were similar phenotypically and functionally to those from the donors matched for HIV status, age, and percentage of NK cells in the peripheral blood. In contrast to previously reported people with CD16A deficiency, this man did not have a history of severe infections with herpes viruses, suggesting that other immune cells and/or immunoregulatory function of NK cells may compensate for deficiency of cytolytic NK cells.

Indexed as

HIV InfectionsKiller Cells, NaturalReceptors, IgGAdultAntibody-Dependent Cell CytotoxicityCytokinesCytotoxicity, ImmunologicHumansImmunophenotypingMaleMonocytesCytokinesFCGR3A protein, humanReceptors, IgGCD16A deficiencyDendritic cell functionFCGR3A deletionMonocyte functionNK cell function

Identifiers

PMID40411624
PMCPMC12103316

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.