Evidence map›Paper›PMID 40411666›Full record

ArticleNeuroscience bulletin2025

OGT-Mediated O-GlcNAcylation of ATF2 Protects Against Sepsis-Associated Encephalopathy by Inhibiting Microglial Pyroptosis.

Huan Yao, Caixia Liang, Xueting Wang, Chengwei Duan, Xiao Song, Yanxing Shang, Mingyang Zhang, Yiyun Peng, Dongmei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huan Yao *Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Caixia Liang *Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Xueting WangMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Chengwei DuanMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Xiao SongDepartment of Emergency, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Yanxing ShangMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Mingyang ZhangMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Yiyun PengMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Dongmei ZhangMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China. zdm_ntyy@163.com.ORCID http://orcid.org/0000-0002-4132-7363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglial pyroptosis and neuroinflammation have been implicated in the pathogenesis of sepsis-associated encephalopathy (SAE). OGT-mediated O-GlcNAcylation is involved in neurodevelopment and injury. However, its regulatory function in microglial pyroptosis and involvement in SAE remains unclear. In this study, we demonstrated that OGT deficiency augmented microglial pyroptosis and exacerbated secondary neuronal injury. Furthermore, OGT inhibition impaired cognitive function in healthy mice and accelerated the progression in SAE mice. Mechanistically, OGT-mediated O-GlcNAcylation of ATF2 at Ser44 inhibited its phosphorylation and nuclear translocation, thereby amplifying NLRP3 inflammasome activation and promoting inflammatory cytokine production in microglia in response to LPS/Nigericin stimulation. In conclusion, this study uncovers the critical role of OGT-mediated O-GlcNAcylation in modulating microglial activity through the regulation of ATF2 and thus protects against SAE progression.

Indexed as

Activating Transcription Factor 2MicrogliaN-AcetylglucosaminyltransferasesPyroptosisSepsis-Associated EncephalopathyAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutActivating Transcription Factor 2Atf2 protein, mouseN-AcetylglucosaminyltransferasesOgt protein, mouseActivation transcription factor 2 (ATF2)MicrogliaO-GlcNAc transferase (OGT)PyroptosisSepsis-associated encephalopathy (SAE)

Identifiers

PMID40411666
PMCPMC12494526

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.