Trial reportThe American journal of clinical nutrition2025
The effects of the Multicultural Healthy Diet on cognitive decline and Alzheimer's disease risk: a phase II randomized controlled trial in middle-aged adults.
Trial report in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03240406 (Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer's Disease Risk), which is not on this map. Cited by 2 papers.
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Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer's Disease Risk
Who cites it
2 citing papers in PubMed.
- Biofortification of Vegetables with Iodine and Molybdenum for Healthy Nutrition: A Controlled Trial.Nutrients · 2025Trial
- Recruitment of mid-life adults to a randomized clinical trial: The multicultural healthy diet study to reduce cognitive decline and Alzheimer's disease risk.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundAnti-inflammatory dietary patterns are associated with slower cognitive decline in older adults; however, little is known about the effects of an anti-inflammatory dietary pattern in middle age.
objectivesThis study aims to adapt an anti-inflammatory diet to a multicultural setting and assess its impact on cognitive decline and Alzheimer's disease risk and related dementias in healthy middle-aged adults.
methodsWe performed a phase II pilot randomized clinical trial in adults (40-65 y old; n = 290) in Bronx, New York. Participants were assigned to follow either the Multicultural Healthy Diet (MHD), an anti-inflammatory diet, or usual diet (Comparison). Diet was evaluated using the National Cancer Institute's Automated Self-Administered 24-h food records. The primary cognitive outcome was assessed at 9 mo after randomization using a global composite score derived from 3 ambulatory cognitive assessments of visuospatial memory (Grid Memory), processing speed (Symbol Search) and short-term associative memory binding (Color Shapes). Secondary outcomes included performance on individual tests and association of dietary components with cognitive performance.
resultsAt 9-mo follow-up, the MHD arm had a lower Dietary Inflammatory Index (DII) score based on self-reported diet, with an adjusted MHD minus Comparison difference of -0.64 [95% confidence interval (CI): -1.02, -0.27] and -0.94 (95% CI: -1.34, -0.54) for the DII and energy-adjusted DII scores, respectively, indicating intervention participants had adhered to an anti-inflammatory dietary pattern. Group session and telephone contact completion averaged 93% and 72%, respectively, for the MHD arm. No statistically significant difference between arms was found in the primary outcome-cognitive global score change-from baseline: -0.06 (95% CI: -0.15, 0.04), P = .259.
conclusionsThe MHD is feasible and acceptable in this multicultural United States cohort. Although the influence of MHD at 9 mo is nonsignificant based on the global composite cognitive score, additional research using other measures such as day-to-day variability in cognitive function and peak performance is warranted. This study was registered at clinicaltrials.gov as NCT03240406 (https://clinicaltrials.gov/study/NCT03240406?term=Diet%20%26%20Cognition&page=3&rank=30).
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