Evidence map›Paper›PMID 40412992›Full record

ReviewGastrointestinal endoscopy clinics of North America2025

Reflux Testing: Wireless pH, Impedance-pH, and Mucosal Impedance.

Amanda Krause, Rena Yadlapati

Abstract readReview
In one paragraph

Review in Gastrointestinal endoscopy clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amanda KrauseDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Diego, La Jolla, CA, USA.
Rena YadlapatiDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Diego, La Jolla, CA, USA. Electronic address: ryadlapati@health.ucsd.edu.

Funding

Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal RefluxR01DK139089 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rena Hiren Yadlapati · 2024 to 2026
$2.0M
Mechanism Guided Therapy for Laryngopharyngeal RefluxK23DK125266 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2021 to 2025
$963k
Role of Psychological Processes on Symptom Burden in Laryngopharyngeal RefluxR03DK135513 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2023 to 2024
$245k
NIDDK NIH HHS K23 DK125266NIDDK NIH HHS R01 DK139089NIDDK NIH HHS R03 DK135513NIDDK NIH HHS T32 DK007202
6 · The paper itself

Abstract

Reflux-like symptoms are common; however, not always due to gastro-esophageal reflux disease (GERD) and thus objective testing for GERD is critical, particularly prior to long-term or invasive therapy. In the absence of Los Angeles Grades B, C, or D esophagitis on upper endoscopy, ambulatory reflux monitoring off antisecretory therapy with either a 96-h prolonged wireless reflux monitoring or 24-h pH-impedance is recommended. Mucosal impedance testing is an emerging adjunct technology to assess esophageal mucosal integrity. These testing modalities can help establish the presence or absence of proven GERD, and ultimately guide antireflux-targeted treatments.

Indexed as

Esophageal MucosaEsophageal pH MonitoringGastroesophageal RefluxElectric ImpedanceHumansHydrogen-Ion ConcentrationWireless TechnologyDiagnosisEsophageal pH monitoringEsophagusGastroesophageal reflux disease

Identifiers

PMID40412992
PMCPMC12113117

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.