Evidence map›Paper›PMID 40413216›Full record

ArticleNature communications2025

The molecular transition that confers voltage dependence to muscle contraction.

Marina Angelini, Nicoletta Savalli, Federica Steccanella, Savana Maxfield, Serena Pozzi, Marino DiFranco, Stephen C Cannon, Antonios Pantazis, Riccardo Olcese

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Pathogenic CaCommunications biology · 2026
    Article
  3. Article
  4. Review
  5. Decreased Serum 5-HT: Clinical Correlates and Regulatory Role in NMJ of MG.Annals of clinical and translational neurology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marina AngeliniDivision of Molecular Medicine, Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. mangelini@ucla.edu.ORCID http://orcid.org/0000-0003-4621-3784
Nicoletta SavalliDivision of Molecular Medicine, Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Federica SteccanellaDivision of Molecular Medicine, Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Savana MaxfieldDivision of Molecular Medicine, Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Serena PozziDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Marino DiFrancoDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Stephen C CannonDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8428-3690
Antonios PantazisDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0002-6467-1327
Riccardo OlceseDivision of Molecular Medicine, Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. rolcese@ucla.edu.ORCID http://orcid.org/0000-0003-4225-9814

Funding

Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic ParalysisR01AR063182 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI STEPHEN C. CANNON · 2012 to 2026
$6.0M
The Molecular Transitions that Initiate EC Coupling in Skeletal MuscleR35GM131896 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2019 to 2023
$2.0M
Opto-Electrophysiological Method to Study Human Skeletal Muscle ChannelopathiesR21AR080282 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DI FRANCO, MARINO, SHIEH, PERRY · 2022 to 2023
$360k
Hjärnfonden (Swedish Brain Foundation) FO2023-0025NIAMS NIH HHS R01 AR063182NIAMS NIH HHS R21 AR080282NIGMS NIH HHS R35 GM131896U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR063182U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R21AR080282-02RU.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM131896Vetenskapsrådet (Swedish Research Council) 2022-00574
6 · The paper itself

Abstract

What is the molecular origin of voltage dependence in skeletal muscle excitation-contraction? Cholinergic transmission to the muscle fiber triggers action potentials, which are sensed by voltage-gated L-type calcium channels (Ca

Indexed as

Calcium Channels, L-TypeMuscle ContractionMuscle, SkeletalRyanodine Receptor Calcium Release ChannelAction PotentialsAnimalsCalciumHumansKineticsMiceMuscle Fibers, SkeletalPatch-Clamp TechniquesCalciumCalcium Channels, L-TypeRyanodine Receptor Calcium Release Channel

Identifiers

PMID40413216
PMCPMC12103506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.