ArticleBMC infectious diseases2025
Association between advanced lung cancer inflammation index and mortality in critically ill septic patients: analysis of the MIMIC-IV database.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.Frontiers in medicine · 2026Article
- Association between Advanced Lung Cancer Inflammation Index and 30-day mortality in patients with spontaneous intracerebral hemorrhage: a retrospective cohort study.Frontiers in neurology · 2025Article
- The relationship between improved elderly nutritional risk index and short-term all-cause mortality in patients with urinary sepsis: a retrospective cohort study.Frontiers in nutrition · 2025Article
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3 authors.
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Abstract
backgroundSeptic patients often face high mortality rates, influenced by various factors, including inflammation and nutritional status. This study investigates the relationship between the Advanced Lung Cancer Inflammation Index (ALI), an indicator of inflammation and nutritional status, and mortality rates (28-day, in-hospital, and ICU) in septic patients.
methodsWe conducted a retrospective analysis using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, focusing on septic patients. Our primary analysis tools were multivariate logistic regression and restricted cubic spline (RCS) to examine the association between ALI and mortality outcomes. Additionally, subgroup and sensitivity analyses were performed to validate the findings.
resultsThe study included 3,739 septic patients. Results showed that higher ALI levels were significantly associated with reduced 28-day and in-hospital mortality rates. Specifically, a one-unit increment in natural log-transformed ALI was linked to a 16% reduced risk of 28-day mortality (p < 0.001) and a 12% reduced risk of in-hospital mortality (p = 0.002). These findings were consistent across different subgroups, confirming the stability of the results.
conclusionsElevated ALI levels are associated with lower mortality rates in septic patients, suggesting ALI as a potential prognostic marker for this group. However, further large prospective studies are needed to corroborate these findings and explore the implications for clinical practice.
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