Evidence map›Paper›PMID 40413724›Full record

ArticleAging2025

Short-term moderate caloric restriction in the rhesus macaque attenuates markers of ovarian aging in select populations.

Emma S Gargus, Rhea Sharma, Rebecca Gu, Camille Mulcahy, Brian W Johnson, Jing Song, Jungwha Lee, Mary Zelinski, Francesca E Duncan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emma S GargusDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Rhea SharmaDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Rebecca GuDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Camille MulcahyDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Brian W JohnsonDepartment of Comparative Medicine, Histology and Imaging Core, University of Washington, Seattle, WA 98195, USA.
Jing SongDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jungwha LeeDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Mary ZelinskiDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA.
Francesca E DuncanDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Homeostatic to reactive hyaluronan matrices in ovarian reproductive agingR01HD093726 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNCAN, FRANCESCA E., PRITCHARD, MICHELE T · 2018 to 2022
$1.6M
Ovarian Aspects of Caloric RestrictionU01AG021382 · NIA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI ZELINSKI, MARY B. · 2002 to 2004
$919k
Modeling ovarian aging phenotype in mechanically tuned 3D matricesF30AG058387 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GARGUS, EMMA · 2018 to 2021
$155k
NIA NIH HHS F30 AG058387NIA NIH HHS U01 AG021382NICHD NIH HHS R01 HD093726NIH HHS P51 OD011092
6 · The paper itself

Abstract

Ovarian aging results in decreased fertility and endocrine function. In mice, caloric restriction (CR) maintains ovarian function. In this study, we determined whether CR also has a beneficial effect on reproductive longevity in the nonhuman primate (NHP). Ovaries were collected from young (10-13 years) and old (19-26 years) rhesus macaques who were either on a diet of moderate caloric restriction or a control diet for three years. To test the effect of CR on follicle number, follicles were analyzed in histological sections from animals across experimental cohorts: Young Control, Young CR, Old Control, Old CR (

Indexed as

AgingCaloric RestrictionOvaryAnimalsBiomarkersFemaleLongevityMacaca mulattaOvarian FollicleBiomarkersagingcaloric restrictionfibrosisnonhuman primateovarian reserve

Identifiers

PMID40413724
PMCPMC12151502

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.