Evidence map›Paper›PMID 40413726›Full record

ArticleGut microbes2025

Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease.

Da-Ya Zhang, Da Li, Shi-Ju Chen, Li-Jun Zhang, Xu-Li Zhu, Fa-Di Chen, Chen Chen, Qi Wang, Yiping Du, Jian-Xin Xiong and 18 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. The effect of short-term consumption ofExperimental biology and medicine (Maywood, N.J.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Da-Ya ZhangThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0000-0001-6133-8919
Da LiThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0000-0001-5499-4723
Shi-Ju ChenThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0009-0003-4247-620X
Li-Jun ZhangHealth Management Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Xu-Li ZhuDepartment of Gastroenterology, Otog Front Banner People's Hospital, Otog Front Banner, China.
Fa-Di ChenWuzhishan Center for Disease Control and Prevention, Wuzhishan, China.
Chen ChenThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0009-0004-3971-8906
Qi WangThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Yiping DuCardiovascular Surgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Jian-Xin XiongDepartment of Gastroenterology, Hainan Second People's Hospital, Wuzhishan, China.
Shi-Mei HuangThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0009-0000-9417-0876
Xiao-Dong ZhangThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0009-0001-3455-1105
Yan-Ting LvThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Fan ZengThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0009-0002-0631-808X
Run-Xiang ChenThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.ORCID 0009-0003-5801-1896
Xianfeng HuangThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Fengjiao MaoThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Shuo ZhouThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Qicen YaoDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Yuliang HuangThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Runyu ChenThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Ying MoThe Second School of Clinical Medicine, Hainan Medical University, Haikou, China.
Yunqian XieDepartment of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Yue-Hong JiangDepartment of Gastroenterology, The Second People's Hospital of Ledong Li Autonomous County, Ledong Li Autonomous County, China.
Zhai ChenDepartment of Gastroenterology, Dongfang People's Hospital, Dongfang, China.
Cui-Yi MoDepartment of Gastroenterology, Qionghai People's Hospital, Qionghai, China.
Jia-Jia ChenDepartment of Gastroenterology, Qionghai People's Hospital, Qionghai, China.
Fei-Hu BaiDepartment of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota exerts a pivotal influence on the development of Metabolic Associated Fatty Liver Disease (MAFLD), although the specific contributions of individual bacterial strains and their metabolites remain poorly defined. We conducted stool shotgun metagenomic sequencing and plasma untargeted metabolomics in a large prospective cohort comprising 120 MAFLD patients and 120 matched healthy controls. The mechanisms and microbial-derived metabolites involved in MAFLD were further investigated through multi-omics analyses

Indexed as

BacteroidesFatty LiverAdultAnimalsFecal Microbiota TransplantationFecesFemaleGastrointestinal MicrobiomeHumansLiverMaleMetabolomicsMiceMice, Inbred C57BLMiddle AgedProspective StudiesBacteroides uniformisgut microbiotahexadecanedioic acidlipid metabolitesmetabolic associated fatty liver diseasemetabolomics

Identifiers

PMID40413726
PMCPMC12118425

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.