Evidence map›Paper›PMID 40413755›Full record

ReviewAutophagy2025

The pathway of autophagy in the epigenetic landscape of

Abhishek Mishra, Varsha Rawat, Kangling Zhang, Chinnaswamy Jagannath

Abstract readReview
In one paragraph

Review in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abhishek MishraDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX, USA.ORCID 0000-0003-2077-0937
Varsha RawatDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX, USA.
Kangling ZhangDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Chinnaswamy JagannathDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX, USA.

Funding

Novel Stem Cell Immunotherapy for MDR-TuberculosisR01AI161015 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ENDSLEY, JANICE J, JAGANNATH, CHINNASWAMY · 2021 to 2025
$4.8M
A Neonatal Monkey Model of Tuberculosis VaccinationR01AI122070 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GAUDUIN, MARIE-CLAIRE ELISABETH, JAGANNATH, CHINNASWAMY · 2017 to 2021
$4.5M
Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in MacrophagesR01AI184551 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Janice J Endsley, Chinnaswamy Jagannath · 2024 to 2026
$3.8M
A Novel Hyper-Immunogenic Low Virulent BCG vaccine against TuberculosisR01AI175837 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SUBRAMANIAN DHANDAYUTHAPANI · 2023 to 2026
$2.0M
A novel quadruple knockout MTb vaccine against tuberculosis (Supplement Resubmission)R15AI156647 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO · PI DHANDAYUTHAPANI, SUBRAMANIAN · 2021 to 2023
$626k
NIAID NIH HHS R01 AI122070NIAID NIH HHS R01 AI161015NIAID NIH HHS R01 AI175837NIAID NIH HHS R01 AI184551NIAID NIH HHS R15 AI156647
6 · The paper itself

Abstract

Macroautophagy (autophagy) is an evolutionarily conserved process that degrades excess cytoplasmic components, such as protein aggregates and damaged organelles, by encapsulating them within double-membrane autophagosomes. These autophagosomes undergo distinct stages - initiation, phagophore nucleation, expansion, and closure - before fusing with lysosomes (or occasionally endosomes) for degradation and recycling. This process is regulated by ATG (autophagy related) proteins, which govern autophagosome formation and lysosomal fusion. Epigenetic modifications and transcription factors can regulate

Indexed as

AutophagyEpigenesis, GeneticHost-Pathogen InteractionsMycobacterium tuberculosisAnimalsAutophagosomesHumansAutophagyepigeneticshistone modificationhost-pathogen interactionsmicroRNAtuberculosis

Identifiers

PMID40413755
PMCPMC12674466

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.