Evidence map›Paper›PMID 40413757›Full record

ArticleAutophagy2025

Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy.

Raffaella Bonavita, Antonello Prodomo, Giuseppe Cortone, Fulvia Vitale, Marcello Germoglio, Angeleen Fleming, Jesper A Balk, Job de Lange, Maurizio Renna, Francesca M Pisani

Abstract read
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raffaella BonavitaIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italy.ORCID 0000-0003-4729-3712
Antonello ProdomoIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italy.ORCID 0009-0009-5853-1027
Giuseppe CortoneIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italy.ORCID 0009-0003-2040-7414
Fulvia VitaleDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Naples, Italy.ORCID 0009-0000-2595-6939
Marcello GermoglioIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italy.ORCID 0000-0002-4174-8387
Angeleen FlemingDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Jesper A BalkDepartment of Human Genetics, Amsterdam UMC location Vrije Universiteit, Cancer Center Amsterdam, Cancer Biology and Immunology, Van der Boechorstraat 6B, 1081 BT Amsterdam, The Netherlands.
Job de LangeDepartment of Human Genetics, Amsterdam UMC location Vrije Universiteit, Cancer Center Amsterdam, Cancer Biology and Immunology, Van der Boechorstraat 6B, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0002-9002-8829
Maurizio RennaDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Naples, Italy.ORCID 0000-0001-6522-1750
Francesca M PisaniIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italy.ORCID 0000-0002-4591-7571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DDX11 is a DNA helicase involved in critical cellular functions, including DNA replication/repair/recombination as well as sister chromatid cohesion establishment. Bi-allelic mutations of

Indexed as

AutophagyCytoplasmDEAD-box RNA HelicasesDNA HelicasesAutophagosomesCell LineHumansMicrotubule-Associated ProteinsDDX11 protein, humanDEAD-box RNA HelicasesDNA HelicasesMicrotubule-Associated ProteinsAutophagosome biogenesisDDX11DNA helicaseneurodevelopmental disordersSQSTM1/p62Warsaw breakage syndrome

Identifiers

PMID40413757
PMCPMC12674475

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.