Evidence map›Paper›PMID 40413967›Full record

ArticleAtherosclerosis2025

Racial differences in aortic perivascular adipose tissue volume and its association with arterial stiffness in middle-aged men.

Akira Sekikawa, Mengyi Li, Michel Clifton, Kelly Shield, Jiatong Li, Andrea Kozai, Murat Sari, Tina Costacou, Mindy Coccari, Emma Barinas-Mitchell

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akira SekikawaDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: akira@pitt.edu.
Mengyi LiDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Michel CliftonDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kelly ShieldDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Jiatong LiDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Andrea KozaiDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Murat SariDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Tina CostacouDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Mindy CoccariDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Emma Barinas-MitchellDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Arterial Stiffness, Cognition, and Equol (ACE)R01AG074971 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2022 to 2026
$12.7M
Cardiovascular Epidemiology Training ProgramT32HL083825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2008 to 2026
$6.1M
Foreign CohortR01HL068200 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEKIKAWA, AKIRA · 2003 to 2012
$5.6M
NHLBI NIH HHS R01 HL068200NHLBI NIH HHS T32 HL083825NIA NIH HHS R01 AG074971
6 · The paper itself

Abstract

BACKGROUND AND

aimsEctopic fat depots, such as aortic perivascular adipose tissue (aPVAT), are emerging as key factors in cardiovascular health. Individuals of African ancestry have lower ectopic fat levels, including visceral adipose tissue (VAT), than European ancestry. However, racial differences in aPVAT volume and its association with arterial stiffness remain unclear.

methodsThis cross-sectional study examined 325 men aged 40-49 (252 White, 73 African American). aPVAT and VAT were quantified using electron-beam computed tomography, and carotid-femoral pulse wave velocity (cfPWV), the gold standard measure of arterial stiffness, was assessed using a noninvasive testing device. Participant characteristics, aPVAT, and cfPWV were compared by race. Multivariable linear regression models evaluated the association between race and aPVAT and between aPVAT and cfPWV, adjusting for cardiovascular risk and lifestyle factors, body mass index (BMI), and VAT. Interaction terms were included to test race-specific effects.

resultsAfrican Americans had significantly lower aPVAT volume than White Americans (42.7 cm

conclusionsAfrican Americans had lower aPVAT volume than White Americans, primarily explained by differences in VAT. The positive relationship between aPVAT and cfPWV underscores the potential role of aPVAT in arterial stiffness across racial groups. Longitudinal studies are needed to explore causality and mechanisms underlying these associations.

Indexed as

Adipose TissueAdiposityAortaIntra-Abdominal FatVascular StiffnessAdultAortographyBlack or African AmericanCarotid-Femoral Pulse Wave VelocityCross-Sectional StudiesHumansMaleMiddle AgedPulse Wave AnalysisRisk FactorsTomography, X-Ray ComputedAortic perivascular adipose tissue (aPVAT)Arterial stiffnessCarotid-femoral pulse wave velocityEctopic fatRacial differencesVisceral adipose tissue

Identifiers

PMID40413967
PMCPMC12515368

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.