Evidence map›Paper›PMID 40414498›Full record

Trial reportClinical nutrition ESPEN2025

Oxylipin serum profile changes in response to an open-label anti-inflammatory dietary intervention.

Marta Sala-Climent, Esha Lal, Francesca Cedola, Maram Alharthi, Marta Fernandez-Bustamante, Meritxell Agustin-Perez, Abha Singh, Soo-In Choi, Tania Rivera, Katherine Nguyen and 6 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition ESPEN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04999683 (Effect of Anti-inflammatory), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04999683 nacompletednot on this map

Effect of Anti-inflammatory (ITIS) Diet in Rheumatoid Arthritis

TypeinterventionalSponsorUniversity of California, San DiegoRan2018 to 2022Enrolled26ConditionsRheumatoid Arthritis, OsteoarthritisArmsITIS diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marta Sala-ClimentDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Esha LalDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Francesca CedolaDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Maram AlharthiDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Marta Fernandez-BustamanteDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Meritxell Agustin-PerezDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Abha SinghDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Soo-In ChoiDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Tania RiveraDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Katherine NguyenDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Susan LeeDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Shahrokh GolshanPsychiatry, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Tiffany HoltPsychiatry, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Oswald QuehenbergerPharmacology, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Roxana CorasDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA.
Monica GumaDepartment of Medicine, School of Medicine, University of California, 9500 Gilman Drive, San Diego, CA 92093, USA; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA. Electronic address: mguma@health.ucsd.edu.

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

introductionOxylipins are bioactive lipids involved in inflammation. This study evaluated how a 2-week anti-inflammatory diet (ITIS, omega-3/omega-6 ratio of 1:1.5) affects plasma oxylipin profiles in patients with active Rheumatoid Arthritis (RA).

methodsIn an open-label pilot trial, 20 RA patients (≥3 tender and ≥3 swollen joints) followed the ITIS diet. Targeted lipidomics by mass spectrometry was used to quantify oxylipins. Patients were classified as responders or non-responders based on ≥50 % pain reduction (Pain-50). Dietary intake was assessed through diet scores, and statistical analyses were performed using RStudio.

resultsParticipants were predominantly female (90 %) with an average age of 57.1. At baseline, responders consumed more walnuts (p = 0.08), almond milk (p = 0.06), avocado (p = 0.04), and quinoa (p = 0.05), and fewer burgers (p = 0.02). No differences in diet adherence were observed between groups. Baseline oxylipin levels did not differ significantly. However, after the intervention, six oxylipins-5-HETE, 11,12-diHETrE, 14,15-diHETrE, 19,20-DiHDPA, 9-oxo-ODE, and 14,15-EET-differed significantly between responders and non-responders. Notably, oxylipins derived from both arachidonic acid (omega-6) and eicosapentaenoic acid (omega-3) decreased significantly after the diet (p = 0.0006 and p = 0.01, respectively).

conclusionThe anti-inflammatory diet modified circulating levels of both pro- and anti-inflammatory oxylipins. These changes varied by pain response, suggesting that diet can influence inflammatory pathways in RA. Further studies are warranted to clarify the mechanisms linking dietary changes, oxylipin modulation, and clinical outcomes. CLINICAL TRIALS IDENTIFIER: NCT04999683.

Indexed as

Anti-Inflammatory AgentsArthritis, RheumatoidDietOxylipinsAdultAgedFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansInflammationLipidomicsMaleMiddle AgedPilot ProjectsAnti-Inflammatory AgentsFatty Acids, Omega-3Fatty Acids, Omega-6OxylipinsAnti-inflammatory dietChronic disease nutritionNutritional interventionOxylipinsRheumatoid arthritis

Identifiers

PMID40414498
PMCPMC13004063

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.