Evidence map›Paper›PMID 40414874›Full record

ArticleJournal of nanobiotechnology2025

Tumor microenvironment responsive Mn-based nanoplatform activate cGAS-STING pathway combined with metabolic interference for enhanced anti-tumor therapy.

E Wen, Yu Tian, Yu Chen, Zhigang Wang, Yi Feng, Zhen Liao

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E WenPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Yu TianDepartment of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Yu ChenInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, 641418, People's Republic of China.
Zhigang WangDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China. zhigangwang@cqmu.edu.cn.
Yi FengInstitute of Burn Research Southwest Hospital Third Military Medical University (Army Medical University), Chongqing, 400038, People's Republic of China. fengxiaoyijoy@163.com.
Zhen LiaoMinistry of Education and School of Pharmaceutical Sciences, Wuhan University, 299 Bayi Road, Wuchang District, Wuhan, Hubei, China. liaozhen@whu.edu.cn.

Funding

Joint Project of Pinnacle Disciplinary Group, the Second Affiliated Hospital of Chongqing Medical University 2024201the China Postdoctoral Science Foundation Grant No. 2023M734260, Grant No. 2023TQ0147, Grant No. GZC20233608the Chongqing Natural Science Foundation for postdoctoral CSTB2023NSCQ- BHX0028the National Natural Science Foundation, China 82402572
6 · The paper itself

Abstract

Despite the encouraging developments in tumor immunotherapy, the complex tumor microenvironment (TME) and abnormal energy metabolism persist as key factors facilitating immune escape. Recent research has emphasized the significant potential of the Manganese ions (Mn

Indexed as

Antineoplastic AgentsManganeseManganese CompoundsMembrane ProteinsNanoparticlesNucleotidyltransferasesOxidesTumor MicroenvironmentAnimalsCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHumansHyaluronic AcidImmunotherapyMiceAntineoplastic AgentscGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHyaluronic AcidManganeseManganese Compoundsmanganese oxideMembrane ProteinsNucleotidyltransferasesOxidesReactive Oxygen SpeciesSilicon DioxideSTING1 protein, humanSTING ProteinChemodynamic therapyEnhanced immunotherapyMetabolic inhibitionSTING pathwayTumor microenvironment

Identifiers

PMID40414874
PMCPMC12105397

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.