Evidence map›Paper›PMID 40414932›Full record

ArticleJournal of nanobiotechnology2025

Oral administration of probiotic spores-based biohybrid system for efficient attenuation of Salmonella Typhimurium-induced colitis.

Mengya Niu, Luo Zhao, Shuang Gong, Xinxin Liu, Cuixia Zheng, Jiannan Jiao, Fangfang Wang, Lei Wang

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. MitigatingMicroorganisms · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengya Niu *School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Luo Zhao *School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Shuang GongSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Xinxin LiuSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Cuixia ZhengSecond Clinical Medical College, Translational Medicine Center, Henan University, Kaifeng, 475000, China.
Jiannan JiaoSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Fangfang WangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Lei WangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. wanglei1@zzu.edu.cn.

Funding

Central Plains science and technology innovation leading talent project 234200510005Henan Province Fund for Cultivating Advantageous Disciplines 222301420012Henan Provincial Medical Science and Technology Public Relations Program Provincial-Ministerial Co-Construction Youth Project SBGJ202303041National Natural Science Foundation of China 82272847Program for Innovative Research Team (in Science and Technology) in Henan Province 25IRTSTHN037
6 · The paper itself

Abstract

Salmonella Typhimurium (S. Tm), a Gram-negative pathogenic bacterium, is one of the most common causes of invasive bacterial diseases. Antibiotic therapy remains the principal therapeutic modality for treating S. Tm infection. However, due to the difficulty in precisely targeted pathogenic bacteria after oral administration, the therapeutic effect remains unsatisfactory. Here, we developed an oral probiotic spores-based biohybrid delivery system (BCs@PME-Au) to treat S. Tm-induced colitis. By employing a one-pot metal deposition method, Polymyxin E (PME) acted as a reducing agent to promote the Au

Indexed as

ColitisProbioticsSalmonella InfectionsSalmonella typhimuriumSpores, BacterialAdministration, OralAnimalsAnti-Bacterial AgentsBacillusGoldHumansMaleMetal NanoparticlesMiceMice, Inbred C57BLAnti-Bacterial AgentsGoldAu NPsOral administrationPolymyxin EProbiotic sporesSalmonella Typhimurium-induced colitis

Identifiers

PMID40414932
PMCPMC12105369

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.