Evidence map›Paper›PMID 40414959›Full record

ArticleFluids and barriers of the CNS2025

Choroid plexus enlargement correlates with subcortical tau deposition in progressive supranuclear palsy.

Na Wang, JiaYing Lu, XueLing Liu, JianPeng Liu, YuCheng Lu, ChengLing Xu, SiRong Piao, LiQin Yang, FengTao Liu, YuXin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na Wang *Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
JiaYing Lu *Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
XueLing Liu *Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
JianPeng LiuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
YuCheng LuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
ChengLing XuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
SiRong PiaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
LiQin YangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FengTao LiuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China. liuft110@aliyun.com.
YuXin LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China. liyuxin@fudan.edu.cn.

Funding

Key Projects of "Double First-Class" Initiative of Fudan University XM03231648National Natural Science Foundation of China 82102016National Natural Science Foundation of China 82102132National Natural Science Foundation of China 82402211
6 · The paper itself

Abstract

objectiveThe choroid plexus (CP) has gained renewed attention for its role in waste clearance in neurodegenerative disorders. However, its involvement in progressive supranuclear palsy (PSP) remains unclear. This study aimed to investigate CP volume changes in patients with PSP compared to Parkinson's disease (PD), and explore its relationship with tau deposition in PSP patients.

methodsA total of 204 participants (92 PSP, 78 PD, 34 healthy controls (HC)) underwent structural MRI, with 63 PSP patients receiving

resultsPSP patients exhibited increased CP volume compared to PD and HC groups. The area under the curve value was 0.84 in differentiating PSP from PD, with CP volume and age as predictive variables. In the PSP group, CP volume was positively correlated with mean

conclusionsCP enlargement is a distinguishing feature of PSP and may serve as an imaging biomarker for tau accumulation, offering potential for differentiating PSP from PD.

Indexed as

Choroid PlexusParkinson DiseaseSupranuclear Palsy, Progressivetau ProteinsAgedDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission Tomographytau Proteins18F-FlorzolotauChoroid plexusParkinson’s diseaseProgressive supranuclear palsy

Identifiers

PMID40414959
PMCPMC12105257

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.