ArticleScientific reports2025
Chest CT-determined sarcopenia is associated with poorer functional outcomes in osteoarthritis patients undergoing total knee arthroplasty: a retrospective cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Association between sarcopenia and mortality in patients with osteoarthritis.Clinical rheumatology · 2026Article
- Investigating sarcopenia and mucus plugging by chest computed tomography in patients with severe chronic obstructive pulmonary disease.Scientific reports · 2026Article
- CT-Assessed Body Composition as Predictor of Post-Operative Complications in Lung Cancer Patients.Cancers · 2026Review
- Association between the sarcopenia index and osteoarthritis: a cross-sectional and longitudinal study.European journal of medical research · 2026Article
- Development of an opportunistic chest CT-based nomogram for identifying low muscle mass in hospitalized patients with COPD.Frontiers in medicine · 2026Article
- Deciphering the miRNA-mRNA Interaction Network Regulating Aging Skeletal Muscle in Various Exercise Regimens through Comprehensive Bioinformatics Analysis.Cell biochemistry and biophysics · 2025Review
- Sarcopenia in rheumatic and musculoskeletal diseases: pathophysiology, diagnosis, and management.Rheumatology international · 2025Review
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Authors and funding
9 authors.
Funding
Abstract
Sarcopenia diagnosed via opportunistic computed tomography (CT) is linked to poor postoperative outcomes. This study aimed to investigate the association between chest CT-diagnosed sarcopenia and post-total knee arthroplasty (TKA) functional outcomes. This single-center retrospective cohort study included 158 knee osteoarthritis (KOA) patients who underwent primary TKA between January 2021 and June 2022. Sarcopenia was defined using skeletal muscle index values derived from chest CT images at the T12 vertebral level. Sociodemographic, clinical, and perioperative data were collected, and functional outcomes were assessed via the Hospital for Special Surgery (HSS) score at 6 months postoperatively. Univariate and multivariate analyses identified independent risk factors for poorer postoperative functional outcomes in KOA patients undergoing TKA. The prevalence of sarcopenia in the cohort was 48.7%. At 6 months after TKA, sarcopenic patients had significantly lower HSS scores (P < 0.05). Advanced age (P = 0.025), higher body mass index (P = 0.027), sarcopenia (P = 0.020), and higher postoperative pain scores (P < 0.001) were independently associated with poorer functional outcomes. The results indicate that chest CT-determined sarcopenia is prevalent among KOA patients undergoing TKA and is significantly associated with poorer functional outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.