ArticleCNS neuroscience & therapeutics2025
Impact of NA-1 on Pericyte-Driven Vasoconstriction and Its Role in No-Reflow During Cerebral Ischemia-Reperfusion.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Endothelial Cell-Pericyte Crosstalk in the Brain Balances Microvascular Stability and Plasticity.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Rediscovery of pericytes within the neurovascular unit for cerebral ischemia/reperfusion injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- NMDA Receptor Mediated Mechanisms in the Post-Stroke Brain: From Physiology to Pathology.Biomolecules · 2026Review
- M2 macrophage-derived exosomes mitigate acute inflammation following ischemic stroke.Frontiers in neurology · 2026Article
- The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction-A Novel Biomarker in Patient Assessment.Biomedicines · 2025Review
- Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
backgroundThe no-reflow phenomenon in the ischemic brain following arterial recanalization leads to poor prognosis. Previous studies suggest that the clinically proven NA-1 drug, with disruption of PSD95 in the neuronal terminals alongside the cerebral microvasculature, may inhibit pericytic contraction of microvessels by reducing endothelin-1 secretion.
methodsA 1.5-h tMCAO model using Balb/c mice was employed. In vivo two-photon imaging and immunofluorescence staining were employed to assess the constriction effect of pericytes on capillaries. The impact of NR2B9c/NA-1 administration (intravenously infused at a dose of 10 μmol/kg) on pericyte constriction was evaluated through immunofluorescent staining of brain sections. Additionally, The effect of NA-1 on cerebral perfusion was assessed using laser speckle blood flow monitoring, whole brain slice perfusion, and high-magnification capillary imaging. Enzyme-linked immunosorbent Assay (ELISA) was conducted to determine changes in quantitative ONOO
resultsIn vivo two-photon imaging and immunofluorescence staining revealed that pericyte constriction following ischemia and recanalization resulted in a decreased diameter of capillaries, particularly at the soma and adjacent areas. Notably, capillary obstruction was localized near pericytes. After administration of NA-1, the immunofluorescence staining section showed that the diameter of capillaries at pericytes' soma and in the adjacent parts increased. The ELISA results indicated a reduction in ONOO
conclusionNA-1 inhibits pericyte constriction following ischemia-reperfusion by reducing ET-1 levels. It improves capillary no-reflow in mice, enhances cerebral perfusion, decreases infarct size, and mitigates behavioral deficits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.